Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9641835 | 0.95 | ABCB11 (0.53) | ABCB11KDM4ECYP1A2CYP2C9IDO1 | |
| SCHEMBL9642812 | 0.95 | ABCB11 (0.49) | ABCB11KDM4ECYP1A2CYP2C9IDO1 | |
| SCHEMBL9641997 | 0.92 | KDM4E (0.51) | ABCB11KDM4ECYP1A2CYP2C9IDO1 | |
| SCHEMBL9643280 | 0.87 | ABCB11 (0.64) | ABCB11KDM4ECYP1A2CYP2C9IDO1 | |
| SCHEMBL9642040 | 0.85 | ABCB11 (0.62) | ABCB11KDM4ECYP1A2CYP2C9IDO1 | |
| SCHEMBL9641894 | 0.84 | HTT (0.49) | ABCB11KDM4ECYP1A2PDE4APDE4B | |
| SCHEMBL11005599 | 0.83 | KDM4E (0.44) | ABCB11KDM4ECYP1A2CYP2C9IDO1 | |
| SCHEMBL10786269 | 0.83 | KDM4E (0.44) | ABCB11KDM4ECYP1A2CYP2C9IDO1 | |
| SCHEMBL9642043 | 0.83 | ABCB11 (0.50) | ABCB11KDM4ECYP1A2CYP2C9IDO1 | |
| SCHEMBL9628321 | 0.83 | KDM4E (0.50) | ABCB11KDM4ECYP1A2CYP2C9IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5091558-A | Topical administeration | SYNTEX (U.S.A.) INC. (US) | 1992-02-25 | — | — | US | disclosed |
| EP-0150831-B1 | NAPHTHALENE ANTI-PSORIATIC AGENTS | SYNTEX (U.S.A.) INC. (US) | 1988-08-10 | — | — | EP | disclosed |
| EP-0150831-A2 | Naphthalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1985-08-07 | — | — | EP | disclosed |