Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.54 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PDE2A | O00408 | 1/20 | 0.42 |
| ▸ | PDE5A | O76074 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4802337 | 0.85 | HSD17B10 (0.60) | HSD17B10ALDH1A1VCAM1MAPTKMT2A | |
| SCHEMBL11819145 | 0.82 | ALDH1A1 (0.64) | HSD17B10ALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL8877704 | 0.82 | HSD17B10 (0.51) | HSD17B10ALDH1A1VCAM1MAPTKMT2A | |
| SCHEMBL9022132 | 0.80 | HSD17B10 (0.53) | HSD17B10ALDH1A1VCAM1KMT2AMEN1 | |
| SCHEMBL1131658 | 0.79 | ALDH1A1 (0.62) | HSD17B10ALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL28257783 | 0.79 | ALDH1A1 (0.58) | ALDH1A1MAPTKMT2AMEN1TDP1 | |
| SCHEMBL8512556 | 0.78 | ALDH1A1 (0.56) | HSD17B10ALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL8176237 | 0.78 | ALDH1A1 (0.58) | ALDH1A1MAPTSMN1; SMN2TDP1TSHR | |
| Methane SCHEMBL28281859 | 0.76 | ALDH1A1 (0.57) | ALDH1A1MAPTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL18911092 | 0.76 | HSD17B10 (0.45) | HSD17B10ALDH1A1VCAM1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5084449-A | Bactericides and antiprotozoa agents | DR. KARL THOMAE GMBH (DE) | 1992-01-28 | — | — | US | disclosed |
| US-4992430-A | Anti-bacterial compositions comprising a substituted bis-(4-aminophenyl)-sulfone and a dihydro-folic acid reductase | DR. KARL THOMAE GMBH (DE) | 1991-02-12 | — | — | US | disclosed |
| US-4829058-A | INHIBITORS OF BACTERIA, MYCOBACTERIA AND PLASMODIA | DR. KARL THOMAE GMBH (DE) | 1989-05-09 | — | — | US | disclosed |
| EP-0165422-B1 | SUBSTITUTED BIS-(4-AMINOPHENYL)-SULPHONES, THEIR PREPARATION AND THEIR USE AS MEDICINES | Dr. Karl Thomae GmbH (DE) | 1988-03-09 | — | — | EP | disclosed |
| EP-0165422-A1 | Substituted bis-(4-aminophenyl)-sulphones, their preparation and their use as medicines | Dr. Karl Thomae GmbH (DE) | 1985-12-27 | — | — | EP | disclosed |