Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 3/20 | 0.42 |
| ▸ | CDC25A | P30304 | 1/20 | 0.42 |
| ▸ | CDC25B | P30305 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | APAF1 | O14727 | 1/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | GAPDH | P04406 | 1/20 | 0.33 |
| ▸ | TDP2 | O95551 | 2/20 | 0.33 |
| ▸ | NSD2 | O96028 | 2/20 | 0.33 |
| ▸ | HKDC1 | Q2TB90 | 2/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.33 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.33 |
| ▸ | NQO1 | P15559 | 1/20 | 0.31 |
| ▸ | POR | P16435 | 1/20 | 0.31 |
| ▸ | S100A4 | P26447 | 1/20 | 0.31 |
| ▸ | CES2 | O00748 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9641818 | 0.87 | CDC25A (0.37) | IDO1CDC25ACDC25BALDH1A1LMNA | |
| SCHEMBL9713892 | 0.84 | CDC25A (0.40) | IDO1CDC25ACDC25BPTPN1APAF1 | |
| SCHEMBL9714034 | 0.77 | IDO1 (0.42) | IDO1CDC25ACDC25BPTPN1APAF1 | |
| SCHEMBL9714052 | 0.71 | CDC25A (0.40) | IDO1CDC25ACDC25BPTPN1APAF1 | |
| SCHEMBL10337086 | 0.69 | ALDH1A1 (0.36) | IDO1CDC25ACDC25BAPAF1MITF | |
| SCHEMBL8579585 | 0.68 | CDC25A (0.61) | IDO1CDC25ACDC25BPTPN1APAF1 | |
| SCHEMBL30002656 | 0.68 | CDC25A (0.61) | IDO1CDC25ACDC25BPTPN1APAF1 | |
| SCHEMBL9627964 | 0.66 | CDC25A (0.62) | IDO1CDC25ACDC25BPTPN1APAF1 | |
| SCHEMBL9713898 | 0.65 | CDC25A (0.36) | IDO1CDC25ACDC25BPTPN1APAF1 | |
| SCHEMBL30003153 | 0.65 | ALDH1A1 (0.71) | IDO1CDC25ACDC25BPTPN1APAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5091558-A | Topical administeration | SYNTEX (U.S.A.) INC. (US) | 1992-02-25 | — | — | US | disclosed |
| EP-0150831-B1 | NAPHTHALENE ANTI-PSORIATIC AGENTS | SYNTEX (U.S.A.) INC. (US) | 1988-08-10 | — | — | EP | disclosed |
| EP-0150831-A2 | Naphthalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1985-08-07 | — | — | EP | disclosed |