Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRAS | P01112 | 14/20 | 0.81 |
| ▸ | ESR1 | P03372 | 13/20 | 0.81 |
| ▸ | ESR2 | Q92731 | 13/20 | 0.81 |
| ▸ | TOP1 | P11387 | 2/20 | 0.81 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.80 |
| ▸ | POLB | P06746 | 1/20 | 0.80 |
| ▸ | MAPT | P10636 | 1/20 | 0.80 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.80 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | USP4 | Q13107 | 1/20 | 0.31 |
| ▸ | USP7 | Q93009 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4857581 | 0.96 | HRAS (0.74) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL9713948 | 0.95 | HRAS (0.73) | HRASESR1ESR2TOP1KDM4E | |
| Stallimycin SCHEMBL108585 | 0.90 | HRAS (1.00) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL14002814 | 0.90 | HRAS (1.00) | HRASESR1ESR2TOP1KDM4E | |
| Stallimycin SCHEMBL193003 | 0.89 | KDM4E (1.00) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL14573087 | 0.83 | HRAS (0.55) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL7125320 | 0.82 | HRAS (0.83) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL4852635 | 0.81 | HRAS (0.53) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL22590340 | 0.81 | HRAS (0.80) | HRASESR1ESR2TOP1KDM4E | |
| Hydrochloric Acid SCHEMBL29375648 | 0.81 | KDM4E (0.82) | HRASESR1ESR2TOP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992009574-A2 | POLY-AMINOPYRROLECARBOXAMIDO DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE S.R.L. (IT) | 1992-06-11 | — | — | WO | claimed |
| WO-1992009574-A2 | POLY-AMINOPYRROLECARBOXAMIDO DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE S.R.L. (IT) | 1992-06-11 | — | — | WO | disclosed |