SCHEMBL9714308

SCHEMBL9714308

CC(C)(C)N(NC(=O)c1cccc(F)c1)C(=O)c1cccc(F)c1

nearest known ligand 0.74

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.71
CYP2C9 P11712 1/20 0.71
ABCB1 P08183 5/20 0.64
POLB P06746 1/20 0.63
HDAC1 Q13547 1/20 0.53
HDAC6 Q9UBN7 1/20 0.53
NPC1 O15118 1/20 0.51
HTT P42858 1/20 0.51
RAB9A P51151 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9714502 0.94 CYP3A4 (0.81) CYP3A4CYP2C9ABCB1POLB
SCHEMBL9714496 0.94 POLB (0.73) CYP3A4CYP2C9ABCB1POLB
SCHEMBL9755889 0.88 CYP3A4 (0.58) CYP3A4CYP2C9ABCB1POLBHDAC1
SCHEMBL9755894 0.88 CYP3A4 (0.55) CYP3A4CYP2C9ABCB1POLBHDAC1
SCHEMBL9756403 0.88 CYP3A4 (0.59) CYP3A4CYP2C9ABCB1POLBHDAC1
SCHEMBL9756401 0.88 CYP3A4 (0.56) CYP3A4CYP2C9ABCB1POLBHDAC1
SCHEMBL9756332 0.87 CYP3A4 (0.58) CYP3A4CYP2C9ABCB1POLB
SCHEMBL9756336 0.86 CYP3A4 (0.52) CYP3A4CYP2C9ABCB1POLBHDAC1
SCHEMBL9756378 0.86 CYP3A4 (0.53) CYP3A4CYP2C9ABCB1POLBHDAC1
SCHEMBL9756373 0.86 CYP3A4 (0.56) CYP3A4CYP2C9ABCB1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0245950-B1 INSECTICIDAL N-SUBSTITUTED-N' - SUBSTITUTED-N, N'-DIACYLHYDRAZINES ROHM AND HAAS COMPANY (US) 1992-06-17 EP disclosed
EP-0236618-B1 INSECTICIDAL N'-SUBSTITUTED-N,N'-DIACYLHYDRAZINES ROHM AND HAAS COMPANY (US) 1991-02-27 EP disclosed
US-4985461-A Insecticidal N'-substituted-N,N'-diacylhydrazines ROHM AND HAAS COMPANY (US) 1991-01-15 US disclosed
EP-0236618-A2 Insecticidal N'-substituted-N,N'-diacylhydrazines ROHM AND HAAS COMPANY (US) 1987-09-16 EP disclosed