SCHEMBL9714957

SCHEMBL9714957

C=CC(=O)OC[Si](C)(OO[Si](C)(C)C)O[Si](C)(C)C

nearest known ligand 0.46

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
TSHR P16473 7/20 0.46
HPGD P15428 1/20 0.46
ALDH1A1 P00352 4/20 0.46
CYP3A4 P08684 2/20 0.46
TP53 P04637 3/20 0.41
HIF1A Q16665 3/20 0.41
HSD17B10 Q99714 1/20 0.41
MAPK1 P28482 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
THRB P10828 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL397010 0.89 TSHR (0.47) TSHRHPGDALDH1A1CYP3A4TP53
SCHEMBL18848195 0.83 TSHR (0.42) TSHRHPGDALDH1A1CYP3A4TP53
SCHEMBL1834061 0.78 TSHR (0.47) TSHRHPGDALDH1A1CYP3A4TP53
SCHEMBL395305 0.78 TSHR (0.48) TSHRHPGDALDH1A1CYP3A4TP53
SCHEMBL3113881 0.78 TSHR (0.47) TSHRHPGDALDH1A1CYP3A4TP53
SCHEMBL344379 0.77 TSHR (0.57) TSHRHPGDALDH1A1CYP3A4TP53
SCHEMBL9718848 0.77 TSHR (0.46) TSHRHPGDALDH1A1CYP3A4TP53
SCHEMBL397193 0.77 TSHR (0.50) TSHRHPGDALDH1A1CYP3A4TP53
SCHEMBL9715050 0.77 TSHR (0.47) TSHRHPGDALDH1A1CYP3A4TP53
SCHEMBL9301778 0.76 TSHR (0.60) TSHRHPGDALDH1A1CYP3A4TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0242080-B1 COPOLYMER COMPOSITIONS PARAGON OPTICAL INC (US) 1992-12-16 EP claimed
EP-0242080-A2 Copolymer compositions PARAGON OPTICAL INC (US) 1987-10-21 EP claimed
US-4661573-A INTRAOCULAR AND CONTACT LENSES; COPOLYMER OF PERFLUROALKYL ACRYLATE, ACRYLOXYALKYLPOLYSILOXANE, ACRYLOXYALKYLSILANOL, POLYACRYLOXYALKYLPOLYSILOXANE PARAGON OPTICAL INC. (US) 1987-04-28 US claimed
EP-0242080-B1 COPOLYMER COMPOSITIONS PARAGON OPTICAL INC (US) 1992-12-16 EP disclosed
EP-0242080-A2 Copolymer compositions PARAGON OPTICAL INC (US) 1987-10-21 EP disclosed
US-4661573-A INTRAOCULAR AND CONTACT LENSES; COPOLYMER OF PERFLUROALKYL ACRYLATE, ACRYLOXYALKYLPOLYSILOXANE, ACRYLOXYALKYLSILANOL, POLYACRYLOXYALKYLPOLYSILOXANE PARAGON OPTICAL INC. (US) 1987-04-28 US disclosed