Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.77 |
| ▸ | MEN1 | O00255 | 1/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.71 |
| ▸ | NPC1 | O15118 | 1/20 | 0.70 |
| ▸ | POLB | P06746 | 1/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6571604 | 0.95 | SMN1; SMN2 (0.84) | SMN1; SMN2MEN1KMT2ANPC1POLB | |
| SCHEMBL21098369 | 0.88 | SMN1; SMN2 (0.89) | SMN1; SMN2MEN1KMT2ANPC1POLB | |
| SCHEMBL27557737 | 0.87 | NPC1 (0.74) | SMN1; SMN2MEN1KMT2ANPC1POLB | |
| SCHEMBL10924053 | 0.86 | ALDH1A1 (0.69) | SMN1; SMN2MEN1KMT2ANPC1POLB | |
| SCHEMBL10919809 | 0.86 | ALDH1A1 (0.69) | SMN1; SMN2MEN1KMT2ANPC1POLB | |
| SCHEMBL10850398 | 0.85 | MEN1 (0.71) | SMN1; SMN2MEN1KMT2ANPC1POLB | |
| SCHEMBL10924576 | 0.84 | ALDH1A1 (0.70) | SMN1; SMN2MEN1KMT2ANPC1POLB | |
| SCHEMBL10832177 | 0.84 | CYP1A2 (0.91) | SMN1; SMN2CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL10852240 | 0.84 | NPC1 (0.73) | SMN1; SMN2MEN1KMT2ANPC1POLB | |
| SCHEMBL4484066 | 0.83 | SMN1; SMN2 (0.80) | SMN1; SMN2MEN1KMT2ANPC1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0266979-A2 | Therapeutic agents | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1988-05-11 | — | — | EP | claimed |
| EP-0266980-B1 | PHARMACEUTICAL COMPOSITIONS, COMPRISING A 2,4-DIPHENYL-1,3-DIOXANE DERIVATIVE AND AN INHIBITOR OF THROMBOXANE A2 SYNTHESIS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-10-28 | — | — | EP | disclosed |
| US-4925869-A | REACTIVATING ENZYME ACETYLCHOLINESTERASE INHIBITED BY LETHAL DOSE OF SOMAN | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-05-15 | — | — | US | disclosed |
| US-4908380-A | Substituted 1,3-dioxane ether derivative; thromboxane A2 inhibitor | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-03-13 | — | — | US | disclosed |
| EP-0266979-A2 | Therapeutic agents | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1988-05-11 | — | — | EP | disclosed |
| EP-0266980-A2 | Pharmaceutical compositions, comprising a 2,4-diphenyl-1,3-dioxane derivative and an inhibitor of thromboxane A2 synthesis | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1988-05-11 | — | — | EP | disclosed |