Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.55 |
| ▸ | MAPT | P10636 | 6/20 | 0.55 |
| ▸ | NPC1 | O15118 | 6/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1536494 | 0.85 | RAB9A (0.60) | RAB9AMAPTNPC1ALDH1A1MEN1 | |
| SCHEMBL1536399 | 0.85 | RAB9A (0.60) | RAB9AMAPTNPC1ALDH1A1MEN1 | |
| SCHEMBL10519158 | 0.79 | RAB9A (0.57) | RAB9AMAPTNPC1ALDH1A1MEN1 | |
| SCHEMBL4739602 | 0.77 | RAB9A (0.54) | RAB9AMAPTNPC1ALDH1A1MEN1 | |
| SCHEMBL14000053 | 0.77 | RAB9A (0.51) | RAB9AMAPTNPC1ALDH1A1MEN1 | |
| SCHEMBL10464761 | 0.76 | RAB9A (0.56) | RAB9AMAPTNPC1ALDH1A1MEN1 | |
| SCHEMBL15888611 | 0.76 | RAB9A (0.50) | RAB9AMAPTNPC1ALDH1A1MEN1 | |
| SCHEMBL29598876 | 0.76 | RAB9A (0.50) | RAB9AMAPTNPC1ALDH1A1MEN1 | |
| SCHEMBL13999821 | 0.75 | RAB9A (0.52) | RAB9AMAPTNPC1ALDH1A1MEN1 | |
| SCHEMBL15888548 | 0.75 | RAB9A (0.49) | RAB9AMAPTNPC1ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0343893-B1 | AROMATIC AND HETEROCYCLIC CARBOXAMIDE DERIVATIVES AS ANTINEOPLASTIC AGENTS | PFIZER INC. (US) | 1992-08-05 | — | — | EP | disclosed |
| US-4970318-A | ANTICARBINOGENIC AGENTS | PFIZER INC. (US) | 1990-11-13 | — | — | US | disclosed |
| EP-0343893-A1 | Aromatic and heterocyclic carboxamide derivatives as antineoplastic agents | PFIZER INC. (US) | 1989-11-29 | — | — | EP | disclosed |