SCHEMBL9715955

SCHEMBL9715955

O=c1oc2c(Br)cccc2n1CC#CI

nearest known ligand 0.38

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
ASAH1 Q13510 1/20 0.38
USP2 O75604 1/20 0.34
HPGD P15428 1/20 0.34
TSHR P16473 1/20 0.34
MAPK1 P28482 1/20 0.34
ALDH1A1 P00352 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32
LOXL2 Q9Y4K0 1/20 0.31
MIF P14174 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9716001 0.83 IDO1 (0.35) USP2HPGDTSHRMAPK1ALDH1A1
SCHEMBL9715962 0.80 GAA (0.39) ALDH1A1MIF
SCHEMBL9715956 0.77 IDO1 (0.38) USP2HPGDTSHRMAPK1ALDH1A1
SCHEMBL536696 0.76 MAPK1 (0.62) USP2HPGDTSHRMAPK1ALDH1A1
SCHEMBL4413055 0.72 HPGD (0.60) ASAH1HPGDMAPK1
SCHEMBL9715926 0.71 CBX7 (0.47) ASAH1USP2HPGDTSHRMAPK1
SCHEMBL9715990 0.71 NPC1 (0.57) ASAH1USP2HPGDTSHRMAPK1
SCHEMBL29460879 0.70 NPC1 (0.42) ASAH1
SCHEMBL16475228 0.70 NPC1 (0.42) ASAH1
SCHEMBL9715959 0.69 POLB (0.33) TSHRMAPK1ALDH1A1MIF

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5102898-A Halosubstituted alkyne group; fungicides ROHM AND HAAS COMPANY (US) 1992-04-07 US disclosed