Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8918984 | 1.00 | TSHR (0.35) | TSHRLMNATDP1THRBALDH1A1 | |
| SCHEMBL14157251 | 0.94 | TSHR (0.40) | TSHRLMNATDP1THRBALDH1A1 | |
| SCHEMBL1131 | 0.94 | TSHR (0.40) | TSHRLMNATDP1THRBALDH1A1 | |
| SCHEMBL10851813 | 0.90 | TSHR (0.38) | TSHRLMNATDP1THRBALDH1A1 | |
| SCHEMBL8911782 | 0.90 | TSHR (0.38) | TSHRLMNATDP1THRBALDH1A1 | |
| SCHEMBL25206988 | 0.90 | TSHR (0.38) | TSHRLMNATDP1THRBALDH1A1 | |
| Bromide SCHEMBL28239528 | 0.90 | TSHR (0.38) | TSHRLMNATDP1THRBALDH1A1 | |
| Phosphine SCHEMBL27559693 | 0.90 | TSHR (0.38) | TSHRLMNATDP1THRBALDH1A1 | |
| Hexane SCHEMBL4123692 | 0.90 | TSHR (0.44) | TSHRLMNATDP1THRBALDH1A1 | |
| SCHEMBL8555736 | 0.88 | TSHR (0.35) | TSHRLMNATDP1THRBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2763990-B1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2017-02-22 | — | — | EP | disclosed |
| EP-2763990-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-08-13 | — | — | EP | disclosed |
| US-8658646-B2 | Pyrrolopyrazine kinase inhibitors | HOFFMANN-LAROCHE INC. (US) | 2014-02-25 | — | — | US | disclosed |
| WO-2013030138-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-03-07 | — | — | WO | disclosed |
| US-20130059834-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN-LA ROCHE INC. | 2013-03-07 | — | — | US | disclosed |
| EP-0247019-B1 | ANTIFOULING AND ANTICORROSIVE COATING FOR UNDERWATER STRUCTURES | FINA RESEARCH S.A. (BE) | 1992-04-15 | — | — | EP | disclosed |
| EP-0247019-A2 | Antifouling and anticorrosive coating for underwater structures | FINA RESEARCH S.A. (BE) | 1987-11-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130059834-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | SYK, ZAP70, JAK1 | TSHR 2932/4885LMNA 4873/4885TDP1 619/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.