Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK2 | Q9NRA0 | 2/20 | 0.38 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11687014 | 0.86 | HTT (0.48) | SPHK2SPHK1TSHRALDH1A1TDP1 | |
| SCHEMBL27810820 | 0.85 | TSHR (0.41) | SPHK2SPHK1TSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL9133300 | 0.84 | TSHR (0.38) | SPHK2SPHK1TSHRALDH1A1THRB | |
| SCHEMBL7110791 | 0.84 | TSHR (0.38) | SPHK2SPHK1TSHRALDH1A1THRB | |
| SCHEMBL51186 | 0.84 | TSHR (0.38) | SPHK2SPHK1TSHRALDH1A1THRB | |
| SCHEMBL27789410 | 0.81 | HTT (0.44) | SPHK2SPHK1TSHRALDH1A1TDP1 | |
| SCHEMBL5704471 | 0.81 | SMN1; SMN2 (0.34) | SPHK2SPHK1SMN1; SMN2ALDH1A1TDP1 | |
| SCHEMBL27465393 | 0.80 | SMN1; SMN2 (0.48) | SPHK2SPHK1TSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL27810881 | 0.80 | — | — | |
| SCHEMBL51199 | 0.79 | CYP1A2 (0.35) | SPHK2SPHK1TSHRALDH1A1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5127934-A | STABILIZED COMPOSITIONS COMPRISING ISOTHIAZOLONES AND EPOXIDES | ROHM AND HAAS COMPANY (US) | 1992-07-07 | — | — | US | disclosed |
| EP-0342852-B1 | ORGANIC STABILIZERS | ROHM AND HAAS COMPANY (US) | 1991-12-11 | — | — | EP | disclosed |
| EP-0342852-A1 | Organic stabilizers | ROHM AND HAAS COMPANY (US) | 1989-11-23 | — | — | EP | disclosed |