Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 7/20 | 1.00 |
| ▸ | PDE3A | Q14432 | 7/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | BLM | P54132 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL11168072 | 0.99 | PDE3B (0.97) | PDE3BPDE3ALMNACYP1A2CYP3A4 | |
| SCHEMBL11391653 | 0.86 | PDE3B (0.76) | PDE3BPDE3ALMNACYP1A2CYP3A4 | |
| SCHEMBL11400630 | 0.83 | PDE3B (0.73) | PDE3BPDE3ALMNACYP1A2CYP3A4 | |
| SCHEMBL11158019 | 0.79 | PDE3B (0.74) | PDE3BPDE3ALMNACYP1A2CYP3A4 | |
| SCHEMBL11398470 | 0.78 | PDE3B (0.73) | PDE3BPDE3ALMNACYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL11278036 | 0.77 | PDE3B (0.71) | PDE3BPDE3ALMNACYP1A2CYP3A4 | |
| Quazinone SCHEMBL2463520 | 0.75 | PDE3B (1.00) | PDE3BPDE3ALMNACYP1A2CYP3A4 | |
| SCHEMBL11289617 | 0.75 | PDE3B (0.60) | PDE3BPDE3ALMNACYP1A2CYP3A4 | |
| SCHEMBL1571161 | 0.75 | PDE3B (0.60) | PDE3BPDE3AMEN1PDE2AKMT2A | |
| Quazinone SCHEMBL11279841 | 0.74 | PDE3B (0.97) | PDE3BPDE3ALMNACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0021338-B1 | QUINAZOLINE DERIVATIVES AND PHARMACEUTICAL PREPARATIONS | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1983-10-12 | — | — | EP | claimed |
| US-4256748-A | INOTROPIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1981-03-17 | — | — | US | claimed |
| EP-0021338-A1 | Quinazoline derivatives and pharmaceutical preparations | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1981-01-07 | — | — | EP | claimed |
| EP-0260527-B1 | SYNERGETIC COMBINATION COMPRISING A PHOSPHODIESTERASE INHIBITOR AND A THROMBOXAN-A2-ANTAGONIST, AND THEIR USE OR MANUFACTURE | Dr. Karl Thomae GmbH (DE) | 1992-04-01 | — | — | EP | disclosed |
| EP-0306846-A2 | Synergistic combination comprising a phosphodiesterase inhibitor and a thromboxane-A2 antagonist, and its use or preparation | Dr. Karl Thomae GmbH (DE) | 1989-03-15 | — | — | EP | disclosed |
| EP-0260527-A2 | Synergetic combination comprising a phosphodiesterase inhibitor and a thromboxan-A2-antagonist, and their use or manufacture | Dr. Karl Thomae GmbH (DE) | 1988-03-23 | — | — | EP | disclosed |
| EP-0021338-B1 | QUINAZOLINE DERIVATIVES AND PHARMACEUTICAL PREPARATIONS | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1983-10-12 | — | — | EP | disclosed |
| EP-0054180-A3 | Process for the preparation of imidazoquinazoline derivatives | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1982-12-01 | — | — | EP | disclosed |
| EP-0054180-A2 | Process for the preparation of imidazoquinazoline derivatives | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1982-06-23 | — | — | EP | disclosed |
| EP-0054180-A2 | Process for the preparation of imidazoquinazoline derivatives | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1982-06-23 | — | — | EP | disclosed |
| US-4256748-A | INOTROPIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1981-03-17 | — | — | US | disclosed |
| EP-0021338-A1 | Quinazoline derivatives and pharmaceutical preparations | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1981-01-07 | — | — | EP | disclosed |