Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 9/20 | 0.73 |
| ▸ | PDE3A | Q14432 | 9/20 | 0.73 |
| ▸ | LMNA | P02545 | 1/20 | 0.73 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.73 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.73 |
| ▸ | TSHR | P16473 | 1/20 | 0.73 |
| ▸ | BLM | P54132 | 1/20 | 0.73 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.31 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.31 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.31 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | PDE2A | O00408 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11158019 | 0.85 | PDE3B (0.74) | PDE3BPDE3ALMNACYP1A2CYP3A4 | |
| Quazinone SCHEMBL2463520 | 0.84 | PDE3B (1.00) | PDE3BPDE3ALMNACYP1A2CYP3A4 | |
| Quazinone SCHEMBL120976 | 0.84 | PDE3B (1.00) | PDE3BPDE3ALMNACYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL11280120 | 0.84 | PDE3B (0.73) | PDE3BPDE3ALMNACYP1A2CYP3A4 | |
| SCHEMBL9718399 | 0.83 | PDE3B (1.00) | PDE3BPDE3ALMNACYP1A2CYP3A4 | |
| Quazinone SCHEMBL11279841 | 0.83 | PDE3B (0.97) | PDE3BPDE3ALMNACYP1A2CYP3A4 | |
| SCHEMBL11391653 | 0.82 | PDE3B (0.76) | PDE3BPDE3ALMNACYP1A2CYP3A4 | |
| Bromide SCHEMBL11168072 | 0.82 | PDE3B (0.97) | PDE3BPDE3ALMNACYP1A2CYP3A4 | |
| SCHEMBL11273531 | 0.78 | PDE3B (0.64) | PDE3BPDE3ALMNACYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL11281642 | 0.77 | PDE3B (0.62) | PDE3BPDE3ALMNACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4256748-A | INOTROPIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1981-03-17 | — | — | US | disclosed |