Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 2/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.44 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6345310 | 0.74 | CHRNA7 (0.51) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL9148604 | 0.72 | CHRNA7 (0.40) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL6344857 | 0.70 | CHRNA7 (0.50) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL9430908 | 0.66 | CHRNA7 (0.49) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL9430775 | 0.66 | CHRNA7 (0.49) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL9431645 | 0.66 | CHRNA7 (0.45) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL6343635 | 0.64 | CHRM2 (0.50) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL9431139 | 0.63 | CHRNA7 (0.42) | CHRNA7 | |
| SCHEMBL23763992 | 0.63 | CHRNA7 (0.41) | CHRNA7 | |
| SCHEMBL6346098 | 0.63 | MEN1 (0.49) | CHRM2CHRM4CHRM5CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0323864-A2 | Lipophilic oxadiazoles | MERCK SHARP & DOHME LTD. (GB) | 1989-07-12 | — | — | EP | claimed |
| US-5135935-A | Anticholesterol agents | MERCK & CO., INC. (US) | 1992-08-04 | — | — | US | disclosed |
| EP-0323864-A2 | Lipophilic oxadiazoles | MERCK SHARP & DOHME LTD. (GB) | 1989-07-12 | — | — | EP | disclosed |