Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | PTAFR | P25105 | 14/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9719024 | 0.88 | SMN1; SMN2 (0.46) | ALDH1A1SMN1; SMN2HPGDMEN1HTT | |
| SCHEMBL9719019 | 0.88 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2HPGDMEN1HTT | |
| SCHEMBL9719098 | 0.88 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2HPGDMEN1HTT | |
| SCHEMBL9719916 | 0.88 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2HPGDMEN1HTT | |
| SCHEMBL9719023 | 0.88 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2HPGDMEN1HTT | |
| SCHEMBL9719025 | 0.88 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2HPGDMEN1HTT | |
| SCHEMBL9768066 | 0.88 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2HPGDMEN1HTT | |
| SCHEMBL9724051 | 0.83 | PTAFR (0.44) | PTAFR | |
| SCHEMBL9719017 | 0.83 | PTAFR (0.44) | PTAFR | |
| SCHEMBL9719122 | 0.83 | PTAFR (0.44) | PTAFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5132463-A | Cardiovascular, skin, kidney, respiratory system, and gastrointestinal disorders | MERCK & CO., INC. (US) | 1992-07-21 | — | — | US | disclosed |
| EP-0257921-B1 | NEW 1,3-DIARYL CYCLOPENTANES AND DERIVATIVES THEREOF AS PAF ANTAGONISTS | MERCK & CO. INC. (US) | 1992-04-15 | — | — | EP | disclosed |
| US-5047420-A | Platelet activating factor | MERCK & CO., INC. (US) | 1991-09-10 | — | — | US | disclosed |
| EP-0257921-A2 | New 1,3-diaryl cyclopentanes and derivatives thereof as paf antagonists | MERCK & CO. INC. (US) | 1988-03-02 | — | — | EP | disclosed |