Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CTSC | P53634 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | GLI1 | P08151 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 2/20 | 0.31 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.31 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 2/20 | 0.31 |
| ▸ | NOS3 | P29474 | 1/20 | 0.31 |
| ▸ | NOS1 | P29475 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
| ▸ | HTR2B | P41595 | 1/20 | 0.30 |
| ▸ | ELANE | P08246 | 1/20 | 0.30 |
| ▸ | TPH1 | P17752 | 1/20 | 0.30 |
| ▸ | ALPI | P09923 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.30 |
| ▸ | XIAP | P98170 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Histidine SCHEMBL10455821 | 1.00 | SLC7A5 (0.34) | SLC7A5CYP3A4CTSCCYP1A2GLI1 | |
| Histidine SCHEMBL27902238 | 0.92 | SLC7A5 (0.35) | SLC7A5CYP3A4CTSCCYP1A2HTR2C | |
| Histidine SCHEMBL2586200 | 0.92 | SLC7A5 (0.35) | SLC7A5CYP3A4CTSCCYP1A2HTR2C | |
| Histidine SCHEMBL2586203 | 0.92 | SLC7A5 (0.35) | SLC7A5CYP3A4CTSCCYP1A2HTR2C | |
| D-Histidine SCHEMBL11606906 | 0.92 | SLC7A5 (0.35) | SLC7A5CYP3A4CTSCCYP1A2HTR2C | |
| Histidine SCHEMBL6903283 | 0.89 | TRHR (0.34) | — | |
| Histidine SCHEMBL5583260 | 0.88 | CYP3A4 (0.31) | SLC7A5CYP3A4CTSCCYP1A2 | |
| Histidine SCHEMBL3088582 | 0.88 | CYP3A4 (0.32) | SLC7A5CYP3A4CTSCCYP1A2 | |
| Histidine SCHEMBL3490081 | 0.88 | CYP3A4 (0.32) | SLC7A5CYP3A4CTSCCYP1A2 | |
| Histidine SCHEMBL790243 | 0.88 | CYP3A4 (0.32) | SLC7A5CYP3A4CTSCCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0373904-A1 | Process and composition for increasing brain dopamine release | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1990-06-20 | — | — | EP | claimed |
| US-5118670-A | PROCESS AND COMPOSITION FOR INCREASING BRAIN DOPAMINE RELEASE | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1992-06-02 | — | — | US | disclosed |