Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 13/20 | 0.53 |
| ▸ | EGFR | P00533 | 11/20 | 0.53 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.53 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.53 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.50 |
| ▸ | SYK | P43405 | 1/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.48 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27751267 | 0.83 | ERBB2 (0.58) | ERBB2EGFRERBB3ERBB4GRM4 | |
| SCHEMBL23859935 | 0.82 | ERBB2 (0.57) | ERBB2EGFRERBB3ERBB4SYK | |
| SCHEMBL6979593 | 0.82 | ERBB2 (0.59) | ERBB2EGFRERBB3ERBB4GRM4 | |
| SCHEMBL9719801 | 0.79 | F2 (0.63) | KMT2AALDH1A1MAPT | |
| SCHEMBL6957850 | 0.79 | ERBB2 (0.56) | ERBB2EGFRERBB3ERBB4SYK | |
| SCHEMBL22967411 | 0.79 | ERBB2 (0.56) | ERBB2EGFRERBB3ERBB4GRM4 | |
| SCHEMBL9719818 | 0.79 | ABCB1 (0.48) | SYKRPS6KB1ABCB1HTR1ADRD2 | |
| SCHEMBL9719832 | 0.78 | F2 (0.58) | ABCB1HTR1ADRD2KMT2AALDH1A1 | |
| SCHEMBL20548962 | 0.78 | ERBB2 (0.59) | ERBB2EGFRERBB3ERBB4SYK | |
| SCHEMBL30053083 | 0.77 | GRM4 (0.60) | ERBB2EGFRGRM4LCKAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5157039-A | Lipoxygenase inhibitors | LEO PHARMACEUTICAL PRODUCTS LTD. (DK) | 1992-10-20 | — | — | US | disclosed |
| US-5109009-A | QUINOLINE AND PYRIDINE COMPOUNDS AND INHIBITION OF 5-LIPOXYGENASES THEREWITH | LEO PHARMACEUTICAL PRODUCTS LTD. (DK) | 1992-04-28 | — | — | US | disclosed |
| US-4826987-A | Pyridyl and quinoline derivatives | LEO PHARMACEUTICAL PRODUCTS LTD. (DK) | 1989-05-02 | — | — | US | disclosed |