Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 12/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.46 |
| ▸ | INCENP | Q9NQS7 | 4/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 3/20 | 0.41 |
| ▸ | CTSK | P43235 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CTSV | O60911 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8689284 | 0.80 | SYK (0.54) | SYKAURKBINCENPALDH1A1ABCB1 | |
| SCHEMBL9719880 | 0.78 | SYK (0.58) | SYKAURKBINCENPSLC6A4USP2 | |
| SCHEMBL9719890 | 0.77 | SYK (0.48) | SYKAURKBINCENPSLC6A4USP2 | |
| SCHEMBL19089277 | 0.76 | SYK (0.53) | SYKAURKBINCENPSLC6A4EGFR | |
| SCHEMBL27299165 | 0.74 | SYK (0.49) | SYKAURKBINCENPSLC6A4ABCB1 | |
| SCHEMBL30853451 | 0.72 | SYK (0.67) | SYKAURKBINCENPSLC6A4ABCB1 | |
| SCHEMBL4342702 | 0.72 | SYK (0.67) | SYKAURKBINCENPSLC6A4ABCB1 | |
| SCHEMBL27096930 | 0.71 | SYK (0.55) | SYKAURKBINCENPSLC6A4ABCB1 | |
| SCHEMBL30729929 | 0.71 | SYK (0.55) | SYKAURKBINCENPSLC6A4ABCB1 | |
| SCHEMBL9719877 | 0.71 | CYP1A2 (0.53) | SYKAURKBINCENPSLC6A4USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5157039-A | Lipoxygenase inhibitors | LEO PHARMACEUTICAL PRODUCTS LTD. (DK) | 1992-10-20 | — | — | US | disclosed |
| US-5109009-A | QUINOLINE AND PYRIDINE COMPOUNDS AND INHIBITION OF 5-LIPOXYGENASES THEREWITH | LEO PHARMACEUTICAL PRODUCTS LTD. (DK) | 1992-04-28 | — | — | US | disclosed |
| US-4826987-A | Pyridyl and quinoline derivatives | LEO PHARMACEUTICAL PRODUCTS LTD. (DK) | 1989-05-02 | — | — | US | disclosed |