SCHEMBL9719798

SCHEMBL9719798

CCCCNc1cccc(OCc2ccccn2)c1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.53
TLR8 Q9NR97 1/20 0.52
TLR7 Q9NYK1 1/20 0.52
GAA P10253 1/20 0.46
MAPT P10636 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
ABCB1 P08183 1/20 0.46
HTR1A P08908 1/20 0.46
DRD2 P14416 1/20 0.46
TLR4 O00206 1/20 0.44
TLR2 O60603 1/20 0.44
GPBAR1 Q8TDU6 2/20 0.43
MEN1 O00255 1/20 0.43
ALDH1A1 P00352 1/20 0.43
KMT2A Q03164 1/20 0.43
CYSLTR2 Q9NS75 1/20 0.43
CYSLTR1 Q9Y271 1/20 0.43
FFAR1 O14842 1/20 0.43
NPC1 O15118 1/20 0.43
RAB9A P51151 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9719825 0.85 NPC1 (0.56) CYP1A2TLR8TLR7SMN1; SMN2ALDH1A1
SCHEMBL20565351 0.81 MAOB (0.56) CYP1A2GAAMAPTMEN1ALDH1A1
SCHEMBL9719835 0.81 APP (0.55) GAAMAPTSMN1; SMN2ABCB1HTR1A
SCHEMBL9719832 0.79 F2 (0.58) GAAMAPTABCB1HTR1ADRD2
SCHEMBL28044727 0.79 CYP1A2 (0.49) CYP1A2MAPTSMN1; SMN2MEN1ALDH1A1
SCHEMBL28807452 0.78 TLR4 (0.49) CYP1A2GAAMAPTSMN1; SMN2ABCB1
SCHEMBL8781060 0.77 MEN1 (0.61) CYP1A2SMN1; SMN2MEN1ALDH1A1KMT2A
SCHEMBL791890 0.76 FFAR1 (0.61) ABCB1HTR1ADRD2TLR4TLR2
SCHEMBL12520413 0.76 MTNR1B (0.60) MAPTSMN1; SMN2MEN1ALDH1A1KMT2A
SCHEMBL9719790 0.75 SMN1; SMN2 (0.59) GAAMAPTSMN1; SMN2MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5157039-A Lipoxygenase inhibitors LEO PHARMACEUTICAL PRODUCTS LTD. (DK) 1992-10-20 US disclosed
US-5109009-A QUINOLINE AND PYRIDINE COMPOUNDS AND INHIBITION OF 5-LIPOXYGENASES THEREWITH LEO PHARMACEUTICAL PRODUCTS LTD. (DK) 1992-04-28 US disclosed
US-4826987-A Pyridyl and quinoline derivatives LEO PHARMACEUTICAL PRODUCTS LTD. (DK) 1989-05-02 US disclosed