Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | SYK | P43405 | 1/20 | 0.46 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.43 |
| ▸ | FABP1 | P07148 | 1/20 | 0.42 |
| ▸ | FABP6 | P51161 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9719857 | 0.82 | SYK (0.50) | ALDH1A1KMT2ASYKPTGES2SMN1; SMN2 | |
| SCHEMBL9719801 | 0.79 | F2 (0.63) | ALDH1A1KMT2AMEN1PKMF2 | |
| SCHEMBL9719818 | 0.79 | ABCB1 (0.48) | ALDH1A1KMT2AMEN1SYKPKM | |
| SCHEMBL9719832 | 0.78 | F2 (0.58) | ALDH1A1KMT2AMEN1PKMF2 | |
| SCHEMBL28049606 | 0.78 | SYK (0.57) | ALDH1A1KMT2AMEN1SYKSMN1; SMN2 | |
| SCHEMBL22002088 | 0.76 | KDM4E (0.55) | ALDH1A1KMT2AMEN1F2SMN1; SMN2 | |
| SCHEMBL5436700 | 0.76 | TACR3 (0.52) | KMT2AMEN1SMN1; SMN2ABCB1TP53 | |
| SCHEMBL9719821 | 0.76 | SYK (0.58) | ALDH1A1SYKPTGES2SMN1; SMN2KDM4E | |
| SCHEMBL9719782 | 0.75 | ERBB2 (0.53) | ALDH1A1KMT2ASYKABCB1HTR1A | |
| SCHEMBL3230243 | 0.74 | PPARA (0.54) | ALDH1A1KMT2AMEN1PTGES2F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5157039-A | Lipoxygenase inhibitors | LEO PHARMACEUTICAL PRODUCTS LTD. (DK) | 1992-10-20 | — | — | US | disclosed |
| US-5109009-A | QUINOLINE AND PYRIDINE COMPOUNDS AND INHIBITION OF 5-LIPOXYGENASES THEREWITH | LEO PHARMACEUTICAL PRODUCTS LTD. (DK) | 1992-04-28 | — | — | US | disclosed |
| US-4826987-A | Pyridyl and quinoline derivatives | LEO PHARMACEUTICAL PRODUCTS LTD. (DK) | 1989-05-02 | — | — | US | disclosed |