Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | CA12 | O43570 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | CA7 | P43166 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10136528 | 0.86 | HTT (0.48) | HTTGAAABL1SLC6A3MEN1 | |
| SCHEMBL23728148 | 0.84 | CFTR (0.42) | HTTGAALMNAKDM4EMAPT | |
| SCHEMBL28068824 | 0.80 | ABL1 (0.57) | HTTABL1SLC6A3MEN1LMNA | |
| SCHEMBL4278397 | 0.80 | ABL1 (0.53) | HTTABL1SLC6A3MEN1LMNA | |
| SCHEMBL28015554 | 0.79 | LMNA (0.38) | GAASLC6A3LMNASMN1; SMN2HPGD | |
| SCHEMBL1953848 | 0.79 | GAA (0.58) | HTTGAAABL1SLC6A3MEN1 | |
| SCHEMBL31739075 | 0.76 | SOS1 (0.40) | SLC6A3LMNASMN1; SMN2HPGDKDM4E | |
| SCHEMBL19328690 | 0.75 | GAA (0.55) | HTTGAAABL1MEN1LMNA | |
| SCHEMBL70011 | 0.75 | GAA (0.58) | HTTGAAABL1MEN1LMNA | |
| SCHEMBL16034830 | 0.75 | NR4A2 (0.48) | HTTGAASLC6A3SMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5151435-A | Hypotensive agents, glaucoma and cognition activators | MERCK & CO., INC. (US) | 1992-09-29 | — | — | US | disclosed |