Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 2/20 | 0.54 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.52 |
| ▸ | TOP2A | P11388 | 3/20 | 0.48 |
| ▸ | TOP2B | Q02880 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.42 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8851823 | 0.91 | STAT3 (0.54) | STAT3ADRB2TOP2ATOP2BMEN1 | |
| SCHEMBL1345146 | 0.91 | STAT3 (0.65) | STAT3ADRB2TOP2ATOP2BMEN1 | |
| SCHEMBL7578035 | 0.87 | ADRB2 (0.51) | STAT3ADRB2TOP2ATOP2BMEN1 | |
| SCHEMBL9585893 | 0.87 | STAT3 (0.54) | STAT3ADRB2TOP2ATOP2BMEN1 | |
| SCHEMBL10339785 | 0.86 | STAT3 (0.53) | STAT3ADRB2TOP2ATOP2BMEN1 | |
| SCHEMBL7579697 | 0.86 | ADRB2 (0.49) | STAT3ADRB2TOP2ATOP2BMEN1 | |
| SCHEMBL7577114 | 0.86 | ADRB2 (0.47) | STAT3ADRB2TOP2ATOP2BCACNA1F | |
| SCHEMBL7580005 | 0.85 | ADRB2 (0.52) | STAT3ADRB2TOP2ATOP2BMEN1 | |
| SCHEMBL8111555 | 0.84 | STAT3 (0.56) | STAT3ADRB2TOP2ATOP2BMEN1 | |
| SCHEMBL7599453 | 0.83 | ADRB2 (0.65) | STAT3ADRB2TOP2ATOP2BKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5169853-A | Antibacterial agents; administering to mammals for infection | STERLING DRUG INC. (US) | 1992-12-08 | — | — | US | disclosed |
| US-5075319-A | Bactericides | STERLING DRUG INC. (US) | 1991-12-24 | — | — | US | disclosed |
| EP-0417669-A2 | Pyridinyl-quinolone compounds, their preparation and use | STERLING WINTHROP INC. (US) | 1991-03-20 | — | — | EP | disclosed |
| EP-0309789-A1 | 4-Oxo-3-quinolinecarboxylic acids useful as antibacterial agents and preparation thereof | STERLING WINTHROP INC. (US) | 1989-04-05 | — | — | EP | disclosed |