Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 2/20 | 0.67 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9724688 | 0.99 | CHRM2 (0.65) | CHRM2CHRM1KCNH2 | |
| SCHEMBL194766 | 0.80 | CHRM2 (1.00) | CHRM2CHRM1 | |
| Oxadiazole SCHEMBL9369455 | 0.77 | CHRM2 (1.00) | CHRM2CHRM1KCNH2 | |
| SCHEMBL9724615 | 0.77 | CHRM2 (0.67) | CHRM2CHRM1 | |
| SCHEMBL5921954 | 0.77 | CHRM2 (0.67) | CHRM2CHRM1 | |
| Hydrochloric Acid SCHEMBL9724715 | 0.75 | CHRM2 (0.65) | CHRM2CHRM1 | |
| Hydrochloric Acid SCHEMBL9653117 | 0.75 | CHRM2 (0.64) | CHRM2CHRM1 | |
| Hydrochloric Acid SCHEMBL9724734 | 0.75 | CHRM2 (0.64) | CHRM2CHRM1 | |
| SCHEMBL9375366 | 0.73 | CHRM2 (0.35) | CHRM2CHRM1 | |
| Hydrochloric Acid SCHEMBL10519400 | 0.73 | CHRM2 (0.62) | CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0459568-A2 | Substituted oxadiazoles and thiadiazoles for use in the treatment of glaucoma and novel compounds having such use | MERCK SHARP & DOHME LTD. (GB) | 1991-12-04 | — | — | EP | claimed |
| JP-4235985-A | — | — | None | — | — | JP | disclosed |
| JP-H04235985-A | SUBSTITUTED OXADIAZOLES AND THIADIAZOLES FOR TREATMENT OF GLAUCOMA AND NEW COMPOUND HAVING APPLICATION THEREFOR | MERCK SHARP & DOHME LTD | 1992-08-25 | — | — | JP | disclosed |
| US-5134146-A | SUBSTITUTED OXADIAZOLES AND THIADIAZOLES FOR USE IN THE TREATMENT OF GLAUCOMA | MERCK SHARP AND DOHME LTD. (GB) | 1992-07-28 | — | — | US | disclosed |
| EP-0459568-A2 | Substituted oxadiazoles and thiadiazoles for use in the treatment of glaucoma and novel compounds having such use | MERCK SHARP & DOHME LTD. (GB) | 1991-12-04 | — | — | EP | disclosed |