Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.49 |
| ▸ | AGTR1 | P30556 | 6/20 | 0.47 |
| ▸ | AGTR2 | P50052 | 4/20 | 0.47 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9552403 | 0.94 | LTB4R2 (0.51) | LTB4R2AGTR1AGTR2PPARG | |
| SCHEMBL9552996 | 0.94 | AGTR1 (0.49) | LTB4R2AGTR1AGTR2PPARG | |
| SCHEMBL9553466 | 0.93 | LTB4R2 (0.51) | LTB4R2AGTR1AGTR2PPARG | |
| SCHEMBL9552258 | 0.90 | AGTR1 (0.45) | LTB4R2AGTR1AGTR2 | |
| SCHEMBL7341321 | 0.90 | LTB4R2 (0.39) | LTB4R2AGTR1AGTR2KDM2BPPARG | |
| SCHEMBL9552237 | 0.89 | AGTR1 (0.46) | LTB4R2AGTR1AGTR2 | |
| SCHEMBL7339270 | 0.89 | KDM2B (0.41) | LTB4R2AGTR1AGTR2KDM2BPPARG | |
| SCHEMBL7338961 | 0.89 | LTB4R2 (0.42) | LTB4R2AGTR1AGTR2PPARG | |
| SCHEMBL7334128 | 0.89 | LTB4R2 (0.38) | LTB4R2AGTR1AGTR2KDM2BPPARG | |
| SCHEMBL9553391 | 0.89 | AGTR1 (0.45) | LTB4R2AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5140036-A | Hypotensive agents; congestive heart failure; angiotensin antagonists | G. D. SEARLE & CO. (US) | 1992-08-18 | — | — | US | disclosed |
| WO-1992005161-A1 | 1,3,5-TRISUBSTITUTED-1,2,4-TRIAZOLE COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS | G.D. SEARLE & CO. (US) | 1992-04-02 | — | — | WO | disclosed |