Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12951732 | 0.80 | KMT2A (0.38) | MAPK1KMT2AHTT | |
| SCHEMBL12950783 | 0.78 | KMT2A (0.39) | MAPK1KMT2APOLBHTT | |
| SCHEMBL20907232 | 0.78 | HTT (0.38) | KMT2AHTT | |
| SCHEMBL9181853 | 0.77 | KMT2A (0.47) | MAPK1KMT2AHTT | |
| SCHEMBL11705079 | 0.75 | NPC1 (0.31) | POLB | |
| SCHEMBL9182433 | 0.74 | KMT2A (0.40) | MAPK1KMT2AHTT | |
| SCHEMBL12951458 | 0.74 | PBRM1 (0.41) | MAPK1KMT2A | |
| SCHEMBL9380054 | 0.72 | MAPT (0.41) | MAPK1KMT2A | |
| SCHEMBL9724132 | 0.72 | KCNJ1 (0.36) | MAPK1KMT2APOLB | |
| SCHEMBL9180114 | 0.71 | CASP3 (0.39) | MAPK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5112837-A | Inhibitors of thymidylate synthetase enzyme | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-05-12 | — | — | US | disclosed |