SCHEMBL9724650

SCHEMBL9724650

NC(=O)c1ccc(C(=O)O)c(C(=O)O)c1C(N)=O

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.44
ALDH1A1 P00352 5/20 0.39
ALOX15 P16050 1/20 0.39
MAPT P10636 5/20 0.38
KDM4E B2RXH2 3/20 0.38
CYP3A4 P08684 2/20 0.38
GAA P10253 1/20 0.38
ESR2 Q92731 1/20 0.38
PTPN1 P18031 1/20 0.38
BCAT2 O15382 1/20 0.38
TSHR P16473 4/20 0.37
HSD17B10 Q99714 4/20 0.37
SELL P14151 1/20 0.37
SELP P16109 1/20 0.37
HPGD P15428 1/20 0.37
CYP2C19 P33261 2/20 0.36
TDP1 Q9NUW8 2/20 0.36
POLB P06746 1/20 0.36
PARP1 P09874 1/20 0.36
RECQL P46063 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9432668 0.95 CYP1A2 (0.48) CYP1A2ALDH1A1ALOX15MAPTKDM4E
SCHEMBL27708034 0.95 CYP1A2 (0.48) CYP1A2ALDH1A1ALOX15MAPTKDM4E
SCHEMBL9432675 0.85 ALDH1A1 (0.46) CYP1A2ALDH1A1MAPTKDM4ECYP3A4
SCHEMBL20603255 0.85 CYP1A2 (0.39) CYP1A2ALDH1A1ALOX15MAPTKDM4E
SCHEMBL34465393 0.85 ALDH1A1 (0.46) CYP1A2ALDH1A1MAPTKDM4ECYP3A4
SCHEMBL1988762 0.83 CYP1A2 (0.61) CYP1A2ALDH1A1ALOX15MAPTKDM4E
SCHEMBL22989 0.83 CYP1A2 (0.61) CYP1A2ALDH1A1ALOX15MAPTKDM4E
SCHEMBL29445717 0.83 CYP1A2 (0.61) CYP1A2ALDH1A1ALOX15MAPTKDM4E
SCHEMBL7093585 0.82 ALDH1A1 (0.50) ALDH1A1ALOX15MAPTKDM4EGAA
SCHEMBL462218 0.82 ALDH1A1 (0.50) ALDH1A1ALOX15MAPTKDM4EGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-4211689-A None JP disclosed
JP-H04211689-A PREPARATION OF (1S-(1ALPHA,2ALPHA(Z),3ALPHA,4ALPHA))-7-(3-(((((1-OXOHEPTYL) AMINO)ACETYL) AMINO)METHYL)-7-OXABICYCLO(2.2.1)HEPT-2-YL)-5-HEPTENOIC ACID E R SQUIBB & SONS INC 1992-08-03 JP disclosed