Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9582350 | 0.85 | TP53 (0.46) | TP53MAPTLMNAMAPK1HTT | |
| SCHEMBL9582482 | 0.85 | TP53 (0.46) | TP53MAPTLMNAMAPK1HTT | |
| SCHEMBL9797567 | 0.77 | TP53 (0.51) | TP53MAPTLMNAMAPK1HTT | |
| SCHEMBL9797671 | 0.77 | TP53 (0.51) | TP53MAPTLMNAMAPK1HTT | |
| SCHEMBL9797786 | 0.77 | TP53 (0.51) | TP53MAPTLMNAMAPK1HTT | |
| SCHEMBL9797149 | 0.77 | TP53 (0.51) | TP53MAPTLMNAMAPK1HTT | |
| SCHEMBL9582408 | 0.74 | AKR1C3 (0.56) | MAPTLMNAHTTALDH1A1USP2 | |
| SCHEMBL10445165 | 0.70 | USP2 (0.77) | MAPTLMNAHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL9354611 | 0.69 | AKR1C3 (0.52) | TP53MAPTLMNAMAPK1HTT | |
| SCHEMBL9727563 | 0.69 | AKR1C3 (0.56) | TP53MAPTLMNAMAPK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4321666-A | — | — | None | — | — | JP | disclosed |
| JP-H04321666-A | 1-ARYLSULFONYL-2-PYRROLIDONE DERIVATIVE, ITS PRODUCTION, OBTAINED NEW INTERMEDIATE, THEIR USE AS PHARMACEUTICAL PREPARATION AND PHARMACEUTICAL COMPOSITION CONTAINING THEM | ROUSSEL UCLAF | 1992-11-11 | — | — | JP | disclosed |