Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 6/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 6/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9797182 | 1.00 | AKR1C3 (0.56) | AKR1C3L3MBTL1TP53LMNAMAPT | |
| SCHEMBL9354611 | 0.97 | AKR1C3 (0.52) | AKR1C3L3MBTL1TP53LMNAMAPT | |
| SCHEMBL9350706 | 0.97 | AKR1C3 (0.52) | AKR1C3L3MBTL1TP53LMNAMAPT | |
| SCHEMBL9351906 | 0.97 | AKR1C3 (0.52) | AKR1C3L3MBTL1TP53LMNAMAPT | |
| SCHEMBL9727320 | 0.88 | PKM (0.51) | AKR1C3L3MBTL1TP53LMNAMAPT | |
| SCHEMBL9727348 | 0.87 | LMNA (0.55) | AKR1C3L3MBTL1TP53LMNA | |
| SCHEMBL9797786 | 0.84 | TP53 (0.51) | AKR1C3L3MBTL1TP53LMNAMAPT | |
| SCHEMBL9797567 | 0.84 | TP53 (0.51) | AKR1C3L3MBTL1TP53LMNAMAPT | |
| SCHEMBL9797149 | 0.81 | TP53 (0.51) | AKR1C3L3MBTL1TP53LMNAMAPT | |
| SCHEMBL9797671 | 0.81 | TP53 (0.51) | AKR1C3L3MBTL1TP53LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5164514-A | Antispasmodics | ROUSSEL UCLAF (FR) | 1992-11-17 | — | — | US | claimed |
| US-5081130-A | Antispasmodic agents | ROUSSEL UCLAF (FR) | 1992-01-14 | — | — | US | claimed |
| EP-0335758-A2 | Derivatives of 1-arylsulfonyl-2-pyrolidinone, process for their preparation, their use as medicaments and compositions containing them | ROUSSEL-UCLAF (FR) | 1989-10-04 | — | — | EP | claimed |
| US-5164514-A | Antispasmodics | ROUSSEL UCLAF (FR) | 1992-11-17 | — | — | US | disclosed |
| US-5081130-A | Antispasmodic agents | ROUSSEL UCLAF (FR) | 1992-01-14 | — | — | US | disclosed |
| US-5037822-A | Antispasmodic agent | ROUSSEL-UCLAF (FR) | 1991-08-06 | — | — | US | disclosed |
| US-4990531-A | Antispasmodic agents | ROUSSEL UCLAF (FR) | 1991-02-05 | — | — | US | disclosed |
| EP-0384844-A2 | 1-Arylsulfonyl-pyrrolidine-2-thione or 1-arylsulfonyl-piperidine-2-thione derivatives, process for their preparation, their pharmaceutical use and compositions containing them | ROUSSEL-UCLAF (FR) | 1990-08-29 | — | — | EP | disclosed |
| EP-0335758-A2 | Derivatives of 1-arylsulfonyl-2-pyrolidinone, process for their preparation, their use as medicaments and compositions containing them | ROUSSEL-UCLAF (FR) | 1989-10-04 | — | — | EP | disclosed |