Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9724723 | 0.99 | HTR2A (0.35) | HTR2AHTR2CHTR2BCHRM2CHRM4 | |
| SCHEMBL9724740 | 0.82 | HTR2A (0.37) | HTR2AHTR2CHTR2BCHRM2CHRM4 | |
| Hydrochloric Acid SCHEMBL9724780 | 0.81 | HTR2A (0.36) | HTR2AHTR2CHTR2BCHRM2CHRM4 | |
| SCHEMBL10586761 | 0.81 | HTR2A (0.36) | HTR2AHTR2CHTR2BCHRM2CHRM4 | |
| SCHEMBL10518946 | 0.78 | USP7 (0.41) | HTR2AHTR2CHTR2B | |
| SCHEMBL10586946 | 0.78 | CHRM2 (0.44) | HTR2AHTR2CHTR2BCHRM2CHRM4 | |
| SCHEMBL10588151 | 0.78 | HTR2A (0.35) | HTR2AHTR2CHTR2BCHRM2CHRM4 | |
| SCHEMBL10588391 | 0.78 | HTR2A (0.38) | HTR2AHTR2CHTR2BCHRM2CHRM4 | |
| SCHEMBL10588409 | 0.77 | HTR2A (0.34) | HTR2AHTR2CHTR2BCHRM2CHRM4 | |
| SCHEMBL10589178 | 0.77 | HTR2A (0.34) | HTR2AHTR2CHTR2BCHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0459568-A2 | Substituted oxadiazoles and thiadiazoles for use in the treatment of glaucoma and novel compounds having such use | MERCK SHARP & DOHME LTD. (GB) | 1991-12-04 | — | — | EP | claimed |
| EP-0322034-A2 | Methyl tetrahydropyridyl oxadiazoles | MERCK SHARP & DOHME LTD. (GB) | 1989-06-28 | — | — | EP | claimed |
| US-5134146-A | SUBSTITUTED OXADIAZOLES AND THIADIAZOLES FOR USE IN THE TREATMENT OF GLAUCOMA | MERCK SHARP AND DOHME LTD. (GB) | 1992-07-28 | — | — | US | disclosed |
| EP-0459568-A2 | Substituted oxadiazoles and thiadiazoles for use in the treatment of glaucoma and novel compounds having such use | MERCK SHARP & DOHME LTD. (GB) | 1991-12-04 | — | — | EP | disclosed |
| EP-0322034-A2 | Methyl tetrahydropyridyl oxadiazoles | MERCK SHARP & DOHME LTD. (GB) | 1989-06-28 | — | — | EP | disclosed |