Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 2/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | USP7 | Q93009 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9369814 | 0.79 | CHRM2 (0.54) | CHRM2CHRM1 | |
| SCHEMBL9724660 | 0.76 | HCRTR1 (0.33) | CHRM2HCRTR1HCRTR2HSD11B1 | |
| SCHEMBL10516940 | 0.75 | GPR119 (0.40) | CHRM2CHRM1HCRTR1HCRTR2 | |
| SCHEMBL9370106 | 0.75 | CHRM2 (0.35) | CHRM2CHRM1 | |
| SCHEMBL9451960 | 0.74 | CHRM2 (0.55) | CHRM2CHRM1 | |
| Hydrochloric Acid SCHEMBL10518010 | 0.73 | CHRM2 (0.54) | CHRM2CHRM1 | |
| Hydrochloric Acid SCHEMBL9653117 | 0.72 | CHRM2 (0.64) | CHRM2CHRM1 | |
| SCHEMBL10518263 | 0.72 | CHRM2 (0.36) | CHRM2CHRM1HCRTR1HCRTR2HSD11B1 | |
| Hydrochloric Acid SCHEMBL9724734 | 0.72 | CHRM2 (0.64) | CHRM2CHRM1 | |
| SCHEMBL9150021 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0459568-A2 | Substituted oxadiazoles and thiadiazoles for use in the treatment of glaucoma and novel compounds having such use | MERCK SHARP & DOHME LTD. (GB) | 1991-12-04 | — | — | EP | claimed |
| EP-0323864-A2 | Lipophilic oxadiazoles | MERCK SHARP & DOHME LTD. (GB) | 1989-07-12 | — | — | EP | claimed |
| US-5134146-A | SUBSTITUTED OXADIAZOLES AND THIADIAZOLES FOR USE IN THE TREATMENT OF GLAUCOMA | MERCK SHARP AND DOHME LTD. (GB) | 1992-07-28 | — | — | US | disclosed |
| EP-0459568-A2 | Substituted oxadiazoles and thiadiazoles for use in the treatment of glaucoma and novel compounds having such use | MERCK SHARP & DOHME LTD. (GB) | 1991-12-04 | — | — | EP | disclosed |
| EP-0323864-A2 | Lipophilic oxadiazoles | MERCK SHARP & DOHME LTD. (GB) | 1989-07-12 | — | — | EP | disclosed |