Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 10/20 | 0.52 |
| ▸ | BRD9 | Q9H8M2 | 9/20 | 0.52 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.45 |
| ▸ | PGR | P06401 | 1/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.45 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | PKLR | P30613 | 1/20 | 0.40 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.40 |
| ▸ | BRD7 | Q9NPI1 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | HBB | P68871 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10602234 | 0.88 | BRD4 (0.54) | BRD4BRD9NR3C1PGRPDE4B | |
| SCHEMBL9726549 | 0.88 | NR3C1 (0.44) | BRD4BRD9NR3C1PGRPDE4B | |
| SCHEMBL10602679 | 0.88 | NR3C1 (0.44) | BRD4BRD9NR3C1PGRPDE4B | |
| SCHEMBL9726518 | 0.81 | BRD4 (0.51) | BRD4BRD9KAT2BBRPF1BRD7 | |
| SCHEMBL10601357 | 0.72 | BRD4 (0.41) | BRD4BRD9KAT2BPKMPKLR | |
| SCHEMBL9726399 | 0.71 | BRD4 (0.49) | BRD4BRD9KAT2BMAPTGAA | |
| SCHEMBL9726575 | 0.69 | BRD4 (0.47) | BRD4BRD9KAT2BBPTF | |
| SCHEMBL9726418 | 0.69 | KDM4E (0.46) | BRD4BRD9MAPTKDM4EMEN1 | |
| SCHEMBL10601520 | 0.68 | BRD4 (0.74) | BRD4BRD9NR3C1KAT2BCNR2 | |
| SCHEMBL12497134 | 0.68 | GAA (0.45) | BRD4KAT2BMAPTMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5098900-A | Reducing contractions in smooth muscles | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1992-03-24 | — | — | US | disclosed |
| EP-0186817-B1 | 3(2H)PYRIDAZINONE, PROCESS FOR ITS PREPARATION AND ANTI-ALLERGIC AGENT CONTAINING IT | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1989-08-02 | — | — | EP | disclosed |
| EP-0186817-A1 | 3(2H)pyridazinone, process for its preparation and anti-allergic agent containing it | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1986-07-09 | — | — | EP | disclosed |