Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.82 |
| ▸ | RAB9A | P51151 | 4/20 | 0.82 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.71 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.69 |
| ▸ | HTT | P42858 | 3/20 | 0.69 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.69 |
| ▸ | GAA | P10253 | 2/20 | 0.69 |
| ▸ | NPC1 | O15118 | 3/20 | 0.68 |
| ▸ | HPGD | P15428 | 3/20 | 0.61 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 4/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.55 |
| ▸ | PGR | P06401 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.55 |
| ▸ | PDE4A | P27815 | 1/20 | 0.55 |
| ▸ | HRH1 | P35367 | 1/20 | 0.55 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3809736 | 0.93 | MAPT (0.82) | MAPTRAB9AKMT2AMAPK1HTT | |
| SCHEMBL9662542 | 0.91 | MAPT (0.68) | MAPTRAB9AKMT2AMAPK1HTT | |
| SCHEMBL4743098 | 0.90 | MAPT (1.00) | MAPTRAB9AKMT2AMAPK1HTT | |
| SCHEMBL27983727 | 0.90 | HTT (0.69) | MAPTRAB9AKMT2AMAPK1HTT | |
| SCHEMBL7091405 | 0.89 | RAB9A (0.65) | MAPTRAB9AKMT2AMAPK1HTT | |
| SCHEMBL13193975 | 0.88 | MAPT (0.65) | MAPTRAB9AKMT2AMAPK1HTT | |
| SCHEMBL30823770 | 0.87 | MAPT (0.73) | MAPTRAB9AKMT2AMAPK1HTT | |
| SCHEMBL3468717 | 0.87 | MAPT (0.73) | MAPTRAB9AKMT2AMAPK1HTT | |
| SCHEMBL30574108 | 0.87 | MAPT (0.73) | MAPTRAB9AKMT2AMAPK1HTT | |
| SCHEMBL11711133 | 0.87 | MAPT (0.73) | MAPTRAB9AKMT2AMAPK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5110940-A | Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase | BRISTOL-MYERS COMPANY (US) | 1992-05-05 | — | — | US | disclosed |
| US-5068346-A | Anticholesterol agents | BRISTOL-MYERS COMPANY (US) | 1991-11-26 | — | — | US | disclosed |
| US-4897490-A | DERIVATIVES OF BETA-HYDROXY,OMEGA-DIPHENYL,TETRAZOL-5-YL ALK-OMEGA-ENOIC ACID, ESTER OR LACTONE | BRISTOL-MEYERS COMPANY (US) | 1990-01-30 | — | — | US | disclosed |
| WO-1988006584-A1 | ANTIHYPERCHOLESTEROLEMIC TETRAZOLE COMPOUNDS | BRISTOL-MYERS COMPANY (US) | 1988-09-07 | — | — | WO | disclosed |
| US-4115413-A | ACID FREE | BAYER AKTIENGESELLSCHAFT (DE) | 1978-09-19 | — | — | US | disclosed |