Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HMGCR | P04035 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9726768 | 0.88 | HMGCR (0.36) | ALDH1A1SMN1; SMN2NPC1RAB9ATP53 | |
| SCHEMBL9726524 | 0.88 | HMGCR (0.36) | ALDH1A1SMN1; SMN2NPC1RAB9ATP53 | |
| SCHEMBL9726571 | 0.87 | HMGCR (0.35) | ALDH1A1SMN1; SMN2NPC1RAB9ATP53 | |
| SCHEMBL9726576 | 0.87 | HMGCR (0.41) | ALDH1A1SMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL9799375 | 0.79 | SMN1; SMN2 (0.37) | ALDH1A1SMN1; SMN2NPC1RAB9ATP53 | |
| SCHEMBL9799379 | 0.79 | SMN1; SMN2 (0.37) | ALDH1A1SMN1; SMN2NPC1RAB9ATP53 | |
| SCHEMBL9726563 | 0.77 | HMGCR (0.44) | HMGCR | |
| SCHEMBL9726457 | 0.76 | HMGCR (0.43) | ALDH1A1SMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL9726462 | 0.76 | HMGCR (0.43) | ALDH1A1SMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL9726655 | 0.76 | HMGCR (0.37) | ALDH1A1SMN1; SMN2NPC1RAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5110940-A | Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase | BRISTOL-MYERS COMPANY (US) | 1992-05-05 | — | — | US | claimed |
| WO-1988006584-A1 | ANTIHYPERCHOLESTEROLEMIC TETRAZOLE COMPOUNDS | BRISTOL-MYERS COMPANY (US) | 1988-09-07 | — | — | WO | claimed |
| US-5110940-A | Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase | BRISTOL-MYERS COMPANY (US) | 1992-05-05 | — | — | US | disclosed |
| US-5068346-A | Anticholesterol agents | BRISTOL-MYERS COMPANY (US) | 1991-11-26 | — | — | US | disclosed |
| US-4939265-A | Intermediates and process for the preparation of antihypercholesterolemic tetrazole compounds | BRISTOL-MYERS COMPANY (US) | 1990-07-03 | — | — | US | disclosed |
| US-4898949-A | Intermediates for the preparation of antihypercholesterolemic tetrazole compounds | BRISTOL-MYERS COMPANY (US) | 1990-02-06 | — | — | US | disclosed |
| US-4897490-A | DERIVATIVES OF BETA-HYDROXY,OMEGA-DIPHENYL,TETRAZOL-5-YL ALK-OMEGA-ENOIC ACID, ESTER OR LACTONE | BRISTOL-MEYERS COMPANY (US) | 1990-01-30 | — | — | US | disclosed |
| WO-1988006584-A1 | ANTIHYPERCHOLESTEROLEMIC TETRAZOLE COMPOUNDS | BRISTOL-MYERS COMPANY (US) | 1988-09-07 | — | — | WO | disclosed |