Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MTOR | P42345 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | THPO | P40225 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | BLM | P54132 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2456414 | 0.88 | KDM4E (0.56) | KDM4ECYP2D6TP53ALOX15MAPT | |
| SCHEMBL2456411 | 0.88 | KDM4E (0.56) | KDM4ECYP2D6TP53ALOX15MAPT | |
| SCHEMBL2456592 | 0.85 | ACHE (0.48) | KDM4ECYP2D6TP53ALOX15MAPT | |
| SCHEMBL2456588 | 0.85 | ACHE (0.48) | KDM4ECYP2D6TP53ALOX15MAPT | |
| SCHEMBL8827770 | 0.83 | ACHE (0.46) | KDM4ECYP2D6CYP1A2HIF1AMEN1 | |
| Acetic Acid SCHEMBL2598906 | 0.83 | KDM4E (0.53) | KDM4ECYP2D6TP53ALOX15MAPT | |
| SCHEMBL8827765 | 0.83 | ACHE (0.46) | KDM4ECYP2D6CYP1A2HIF1AMEN1 | |
| Acetic Acid SCHEMBL2453698 | 0.83 | KDM4E (0.53) | KDM4ECYP2D6TP53ALOX15MAPT | |
| SCHEMBL2453702 | 0.82 | ACHE (0.49) | KDM4ECYP2D6MAPTCYP1A2HIF1A | |
| SCHEMBL2598910 | 0.82 | ACHE (0.49) | KDM4ECYP2D6MAPTCYP1A2HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4983616-A | Analgesics, cognition activators | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-01-08 | — | — | US | claimed |
| US-5091541-A | Useful as alzheimer's disease | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1992-02-25 | — | — | US | disclosed |
| EP-0440145-A1 | Hexahydropyrrolo[2,3-b]indole carbamates,-ureas,-amides and related compounds, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-08-07 | — | — | EP | disclosed |
| US-4983616-A | Analgesics, cognition activators | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-01-08 | — | — | US | disclosed |