Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.65 |
| ▸ | DRD2 | P14416 | 1/20 | 0.65 |
| ▸ | HTR2A | P28223 | 1/20 | 0.65 |
| ▸ | HTR2C | P28335 | 1/20 | 0.65 |
| ▸ | HTR2B | P41595 | 1/20 | 0.65 |
| ▸ | ACHE | P22303 | 2/20 | 0.64 |
| ▸ | BCHE | P06276 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | CCR3 | P51677 | 1/20 | 0.59 |
| ▸ | DRD4 | P21917 | 2/20 | 0.57 |
| ▸ | MAOA | P21397 | 2/20 | 0.57 |
| ▸ | MAOB | P27338 | 2/20 | 0.57 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.56 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9727332 | 1.00 | SIGMAR1 (0.65) | SIGMAR1DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL9727058 | 0.95 | SIGMAR1 (0.74) | SIGMAR1DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL9727061 | 0.95 | SIGMAR1 (0.74) | SIGMAR1DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL9727057 | 0.91 | BCHE (0.57) | SIGMAR1DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL9727062 | 0.91 | BCHE (0.57) | SIGMAR1DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL9852165 | 0.88 | SIGMAR1 (0.65) | SIGMAR1DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL9852171 | 0.88 | SIGMAR1 (0.65) | SIGMAR1DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL9852194 | 0.87 | SIGMAR1 (0.58) | SIGMAR1DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL9852189 | 0.87 | SIGMAR1 (0.58) | SIGMAR1DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL9727145 | 0.86 | SIGMAR1 (0.60) | SIGMAR1DRD2HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5098915-A | Antiarrhythmia agents | G. D. SEARLE & CO. (US) | 1992-03-24 | — | — | US | claimed |
| EP-0416581-A1 | Substituted N-benzylpiperidine amides | G.D. Searle & Co. (US) | 1991-03-13 | — | — | EP | claimed |