Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 14/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 11/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 9/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | XDH | P47989 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11838252 | 0.77 | GAA (0.54) | GAAOPRM1OPRK1OPRD1 | |
| SCHEMBL11319914 | 0.76 | GAA (0.47) | GAAOPRM1OPRK1OPRD1 | |
| SCHEMBL11849291 | 0.73 | GAA (0.50) | GAAOPRM1OPRK1OPRD1 | |
| SCHEMBL9750305 | 0.73 | GAA (0.50) | GAAOPRM1OPRK1OPRD1 | |
| SCHEMBL11851903 | 0.73 | GAA (0.47) | GAAOPRM1OPRK1OPRD1 | |
| SCHEMBL12518457 | 0.69 | OPRM1 (0.49) | GAAOPRM1OPRK1OPRD1 | |
| SCHEMBL11271031 | 0.69 | GAA (0.80) | GAAOPRM1OPRK1OPRD1 | |
| SCHEMBL11258412 | 0.68 | GAA (0.78) | GAAOPRM1OPRK1OPRD1 | |
| SCHEMBL10440418 | 0.67 | GAA (1.00) | GAAOPRM1OPRK1OPRD1 | |
| SCHEMBL9710157 | 0.66 | OPRM1 (0.43) | GAAOPRM1OPRK1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5091533-A | Treating allergies, cardiovascular disorders, inflammation | MERCK FROSST CANADA, INC. (CA) | 1992-02-25 | — | — | US | disclosed |
| EP-0447189-A1 | 5-Hydroxy-2,3-dihydrobenzofuran analogs as leukotriene biosynthesis inhibitors | MERCK FROSST CANADA INC. (CA) | 1991-09-18 | — | — | EP | disclosed |