Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 13/20 | 0.72 |
| ▸ | CHRM1 | P11229 | 12/20 | 0.72 |
| ▸ | CHRM3 | P20309 | 9/20 | 0.72 |
| ▸ | CHRM4 | P08173 | 8/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.66 |
| ▸ | TSHR | P16473 | 1/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | CHRM5 | P08912 | 5/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.61 |
| ▸ | DRD1 | P21728 | 1/20 | 0.61 |
| ▸ | DRD5 | P21918 | 1/20 | 0.61 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9728077 | 0.98 | CHRM2 (0.77) | CHRM2CHRM1CHRM3CHRM4ALDH1A1 | |
| SCHEMBL9727836 | 0.92 | ALDH1A1 (0.68) | CHRM2CHRM1CHRM3CHRM4ALDH1A1 | |
| SCHEMBL8878934 | 0.90 | CHRM2 (0.68) | CHRM2CHRM1CHRM3CHRM4ALDH1A1 | |
| SCHEMBL8880309 | 0.89 | CHRM2 (0.70) | CHRM2CHRM1CHRM3CHRM4ALDH1A1 | |
| SCHEMBL8880358 | 0.87 | CHRM2 (0.72) | CHRM2CHRM1CHRM3CHRM4ALDH1A1 | |
| SCHEMBL9824697 | 0.87 | CHRM2 (0.57) | CHRM2CHRM1CHRM3CHRM4ALDH1A1 | |
| SCHEMBL9727995 | 0.86 | ALDH1A1 (0.81) | CHRM2CHRM1CHRM3CHRM4ALDH1A1 | |
| SCHEMBL8880500 | 0.86 | ALDH1A1 (0.70) | CHRM2CHRM1CHRM3CHRM4ALDH1A1 | |
| SCHEMBL9728149 | 0.86 | ALDH1A1 (0.69) | CHRM2CHRM1CHRM3CHRM4ALDH1A1 | |
| SCHEMBL12648694 | 0.84 | CHRM2 (1.00) | CHRM2CHRM1CHRM3CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5175158-A | CONDENSED DIAZEPINONES, PROCESSES FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS | DR. KARL THOMAE, GMBH (DE) | 1992-12-29 | — | — | US | disclosed |
| EP-0312895-A2 | Condensed diazepinones, process for their preparation and medicament containing them | Dr. Karl Thomae GmbH (DE) | 1989-04-26 | — | — | EP | disclosed |