Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5799328 | 0.79 | TSHR (0.56) | TSHRPOLBHTTALDH1A1KMT2A | |
| SCHEMBL2036528 | 0.75 | TSHR (0.59) | TSHRPOLBHTTALDH1A1KMT2A | |
| SCHEMBL16527290 | 0.74 | HTT (0.55) | TSHRPOLBHTTALDH1A1BLM | |
| SCHEMBL11243429 | 0.72 | TSHR (0.56) | TSHRPOLBHTTALDH1A1KMT2A | |
| SCHEMBL4372909 | 0.72 | TSHR (0.51) | TSHRPOLBHTTALDH1A1BLM | |
| SCHEMBL10817574 | 0.72 | TSHR (0.51) | TSHRHTTALDH1A1BLMKMT2A | |
| SCHEMBL1226609 | 0.71 | TSHR (0.54) | TSHRHTTALDH1A1BLMKMT2A | |
| SCHEMBL917410 | 0.71 | TSHR (0.58) | TSHRHTTALDH1A1KMT2APIK3CD | |
| SCHEMBL30762 | 0.70 | — | — | |
| SCHEMBL948990 | 0.70 | TSHR (0.68) | TSHRPOLBHTTALDH1A1BLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5175158-A | CONDENSED DIAZEPINONES, PROCESSES FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS | DR. KARL THOMAE, GMBH (DE) | 1992-12-29 | — | — | US | disclosed |
| US-4931436-A | BRADYCARDIAL AGENTS | DR. KARL THOMAE GMBH (DE) | 1990-06-05 | — | — | US | disclosed |