Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 9/20 | 0.50 |
| ▸ | HTR2B | P41595 | 5/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.36 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.35 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10231332 | 1.00 | ADRA1A (0.50) | ADRA1AHTR2BADRA2AADRA1DADRA1B | |
| SCHEMBL196337 | 0.89 | — | — | |
| SCHEMBL4585762 | 0.82 | ADRA1A (0.52) | ADRA1AHTR2BADRA2AADRA1DADRA1B | |
| SCHEMBL7809418 | 0.82 | ADRA1A (0.52) | ADRA1AHTR2BADRA2AADRA1DADRA1B | |
| SCHEMBL184451 | 0.81 | ADRA1A (0.55) | ADRA1AHTR2BADRA2AADRA1DADRA1B | |
| SCHEMBL1494449 | 0.81 | — | — | |
| SCHEMBL1543782 | 0.80 | ADRA1A (0.50) | ADRA1AHTR2BADRA2AADRA1DADRA1B | |
| SCHEMBL5163454 | 0.79 | ADRA1A (0.46) | ADRA1AHTR2BADRA2AADRA1DADRA1B | |
| SCHEMBL8077368 | 0.79 | ADRA1A (0.46) | ADRA1AHTR2BADRA2AADRA1DADRA1B | |
| SCHEMBL7856564 | 0.79 | ADRA1A (0.53) | ADRA1AHTR2BADRA2AADRA1DADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5164388-A | Hypotensive agents, treatment of congestive heart failure | ABBOTT LABORATORIES (US) | 1992-11-17 | — | — | US | disclosed |
| EP-0439556-A4 | HETEROCYCLIC PEPTIDE RENIN INHIBITORS | — | 1991-10-30 | — | — | EP | disclosed |