SCHEMBL9728422

SCHEMBL9728422

O=C(O)C(F)(F)C(F)(I)C(F)(F)F

nearest known ligand 0.48

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
THRB P10828 1/20 0.48
ACLY P53396 2/20 0.37
ALDH1A1 P00352 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1923236 0.78 THRB (0.39) THRBACLYALDH1A1
SCHEMBL10717839 0.77 THRB (0.31) THRB
SCHEMBL9869874 0.75 THRB (0.46) THRBACLYALDH1A1L3MBTL1
SCHEMBL63977 0.74 THRB (0.58) THRBACLYALDH1A1L3MBTL1
SCHEMBL508043 0.73 THRB (0.56) THRBACLYALDH1A1L3MBTL1
SCHEMBL5610977 0.73 THRB (0.43) THRBACLYALDH1A1L3MBTL1
SCHEMBL3693057 0.71 THRB (0.55) THRBACLYALDH1A1L3MBTL1
SCHEMBL5963066 0.71 THRB (0.55) THRBACLYALDH1A1L3MBTL1
Water SCHEMBL22069810 0.71 THRB (0.55) THRBACLYALDH1A1L3MBTL1
Fluoride SCHEMBL1898636 0.71 THRB (0.55) THRBACLYALDH1A1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5117055-A Method for direct conversion of fluorocarbonyl group into halogenides AGENCY OF INDUSTRIAL SCIENCE AND TECHNOLOGY (JP) 1992-05-26 US disclosed