Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.78 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.78 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.78 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.64 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | PIM1 | P11309 | 2/20 | 0.47 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.47 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MARK2 | Q7KZI7 | 2/20 | 0.47 |
| ▸ | GSK3A | P49840 | 2/20 | 0.47 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.47 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.47 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11162191 | 0.89 | KDM4E (0.65) | MAP2K1CLK4DYRK1BTLR8KDM4E | |
| Hydrochloric Acid SCHEMBL11366478 | 0.88 | KDM4E (0.64) | MAP2K1CLK4DYRK1BTLR8KDM4E | |
| SCHEMBL8338772 | 0.88 | CLK4 (1.00) | MAP2K1CLK4DYRK1BTLR8KDM4E | |
| SCHEMBL11167079 | 0.87 | MAP2K1 (0.59) | MAP2K1CLK4DYRK1BTLR8KDM4E | |
| SCHEMBL11167453 | 0.86 | MAP2K1 (0.57) | MAP2K1CLK4DYRK1BTLR8KDM4E | |
| SCHEMBL9868803 | 0.85 | MAP2K1 (0.80) | MAP2K1CLK4DYRK1BTLR8KDM4E | |
| SCHEMBL7360098 | 0.85 | MAP2K1 (0.56) | MAP2K1CLK4DYRK1BTLR8KDM4E | |
| SCHEMBL7366580 | 0.84 | MAP2K1 (0.55) | MAP2K1CLK4DYRK1BTLR8KDM4E | |
| SCHEMBL7361400 | 0.84 | CLK4 (0.62) | MAP2K1CLK4DYRK1BTLR8KDM4E | |
| SCHEMBL7364047 | 0.82 | MAP2K1 (0.56) | MAP2K1CLK4DYRK1BTLR8KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5169850-A | Neurotropic or hypotensive agents | AMERICAN CYANAMID COMPANY (US) | 1992-12-08 | — | — | US | disclosed |
| US-5059691-A | Anxiolytic agents; hypotensive agents; nervous system disorders; cognition activators | AMERICAN CYANAMID COMPANY (US) | 1991-10-22 | — | — | US | disclosed |
| US-5013737-A | Hypotensive, anxiolytic, cognitive disorders | AMERICAN CYANAMID COMPANY (US) | 1991-05-07 | — | — | US | disclosed |
| US-4847256-A | HYPOTENSIVE AGENTS | AMERICAN CYANAMID COMPANY (US) | 1989-07-11 | — | — | US | disclosed |
| EP-0025819-B1 | SUBSTITUTED PYRAZOLO (1,5-A) PYRIMIDINES, AND THEIR PREPARATION | AMERICAN CYANAMID COMPANY (US) | 1983-10-12 | — | — | EP | disclosed |
| US-4281000-A | Substituted pyrazolo (1,5-a)pyrimidines and their use as anxiolytic agents | AMERICAN CYANAMID COMPANY (US) | 1981-07-28 | — | — | US | disclosed |
| EP-0025819-A1 | Substituted pyrazolo (1,5-a) pyrimidines, and their preparation | AMERICAN CYANAMID COMPANY (US) | 1981-04-01 | — | — | EP | disclosed |