Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 1.00 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 1.00 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 1.00 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.68 |
| ▸ | PIM1 | P11309 | 6/20 | 0.59 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.59 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.59 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.59 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | GSK3A | P49840 | 4/20 | 0.58 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.58 |
| ▸ | MARK2 | Q7KZI7 | 2/20 | 0.58 |
| ▸ | AKT1 | P31749 | 2/20 | 0.58 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.58 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.58 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.58 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.58 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9868803 | 0.89 | MAP2K1 (0.80) | CLK4MAP2K1DYRK1BTLR8KDM4E | |
| SCHEMBL9728658 | 0.88 | MAP2K1 (0.78) | CLK4MAP2K1DYRK1BTLR8KDM4E | |
| SCHEMBL7362738 | 0.84 | CLK4 (0.73) | CLK4MAP2K1DYRK1BTLR8KDM4E | |
| SCHEMBL8336450 | 0.84 | TLR8 (0.74) | CLK4MAP2K1DYRK1BTLR8KDM4E | |
| SCHEMBL8331920 | 0.84 | TLR8 (1.00) | CLK4MAP2K1DYRK1BTLR8KDM4E | |
| SCHEMBL11464570 | 0.82 | CLK4 (0.70) | CLK4MAP2K1DYRK1BTLR8KDM4E | |
| SCHEMBL8335009 | 0.81 | TLR8 (0.73) | CLK4MAP2K1DYRK1BTLR8KDM4E | |
| SCHEMBL8435070 | 0.81 | KDM4E (1.00) | CLK4MAP2K1DYRK1BTLR8KDM4E | |
| SCHEMBL10336150 | 0.80 | TLR8 (0.71) | CLK4MAP2K1DYRK1BTLR8KDM4E | |
| SCHEMBL7366615 | 0.79 | CLK4 (0.65) | CLK4MAP2K1DYRK1BTLR8KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0957918-A1 | METHOD OF TREATING OR INHIBITING NEUTROPENIA | American Cyanamid Company (US) | 1999-11-24 | — | — | EP | disclosed |
| US-5932585-A | Method of treating or inhibiting neutropenia | AMERICAN CYANAMID COMPANY (US) | 1999-08-03 | — | — | US | disclosed |
| WO-1998026781-A1 | METHOD OF TREATING OR INHIBITING NEUTROPENIA | AMERICAN CYANAMID COMPANY (US) | 1998-06-25 | — | — | WO | disclosed |
| US-5169850-A | Neurotropic or hypotensive agents | AMERICAN CYANAMID COMPANY (US) | 1992-12-08 | — | — | US | disclosed |
| US-5059691-A | Anxiolytic agents; hypotensive agents; nervous system disorders; cognition activators | AMERICAN CYANAMID COMPANY (US) | 1991-10-22 | — | — | US | disclosed |
| US-4916137-A | 5-(Substituted-amino)-8-(phenyl or substituted-phenyl)-3H,6H-1,4,5A,8A-tetraazaacenaphthylen-3-ones and treatment of neural behavior disorders | AMERICAN CYANAMID COMPANY (US) | 1990-04-10 | — | — | US | disclosed |
| EP-0329940-A1 | 5-(substituted)amino)-8- (phenyl or substituted phenyl)-3H,6H-1,2,5,a,8 a-tetraazaacenaphthylen-3-ones | AMERICAN CYANAMID COMPANY (US) | 1989-08-30 | — | — | EP | disclosed |
| US-4847256-A | HYPOTENSIVE AGENTS | AMERICAN CYANAMID COMPANY (US) | 1989-07-11 | — | — | US | disclosed |