Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.46 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 5/20 | 0.41 |
| ▸ | RAB9A | P51151 | 5/20 | 0.41 |
| ▸ | HTT | P42858 | 4/20 | 0.41 |
| ▸ | GALR3 | O60755 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1863191 | 1.00 | KDR (0.46) | KDRTLR8ALDH1A1TDP1NPC1 | |
| SCHEMBL1862049 | 1.00 | KDR (0.46) | KDRTLR8ALDH1A1TDP1NPC1 | |
| SCHEMBL474839 | 0.98 | TLR8 (0.44) | KDRTLR8ALDH1A1TDP1NPC1 | |
| SCHEMBL1860836 | 0.92 | ALDH1A1 (0.44) | KDRTLR8ALDH1A1TDP1POLB | |
| SCHEMBL1859454 | 0.84 | — | — | |
| SCHEMBL6302339 | 0.80 | ALDH1A1 (0.38) | KDRTLR8ALDH1A1TDP1MEN1 | |
| SCHEMBL9020965 | 0.79 | NPC1 (0.42) | KDRALDH1A1NPC1RAB9AHTT | |
| SCHEMBL1857052 | 0.79 | ALDH1A1 (0.41) | ALDH1A1TDP1NPC1RAB9AHTT | |
| SCHEMBL9020584 | 0.79 | NPC1 (0.42) | KDRALDH1A1NPC1RAB9AHTT | |
| SCHEMBL17943853 | 0.79 | NPC1 (0.42) | KDRALDH1A1NPC1RAB9AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5162360-A | Treating hypercholesterolemia and atherosclerosis; ACAT acyl-coenzyme A:-cholesterol acyltransferase | WARNER-LAMBERT COMPANY (US) | 1992-11-10 | — | — | US | disclosed |