Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | GALR3 | O60755 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | KAT2B | Q92831 | 7/20 | 0.52 |
| ▸ | DHFR | P00374 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 3/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | RAD52 | P43351 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3605833 | 0.84 | MAPT (0.51) | MAPTGALR3SMN1; SMN2PDE4APDE4B | |
| Iodide SCHEMBL9729749 | 0.83 | MAPT (0.51) | MAPTGALR3SMN1; SMN2PDE4APDE4B | |
| Iodide SCHEMBL9729167 | 0.83 | MAPT (0.53) | MAPTGALR3SMN1; SMN2PDE4APDE4B | |
| SCHEMBL7273931 | 0.82 | GALR3 (0.79) | MAPTGALR3SMN1; SMN2KAT2BDHFR | |
| SCHEMBL3440851 | 0.79 | MAPT (0.64) | MAPTGALR3SMN1; SMN2PDE4APDE4B | |
| SCHEMBL10429894 | 0.78 | MAPT (0.44) | MAPTGALR3SMN1; SMN2DHFRPDE4A | |
| SCHEMBL10429893 | 0.78 | MAPT (0.44) | MAPTGALR3SMN1; SMN2DHFRPDE4A | |
| SCHEMBL7268573 | 0.77 | MAPT (0.65) | MAPTGALR3SMN1; SMN2KAT2BDHFR | |
| SCHEMBL3441023 | 0.77 | PDE3B (0.50) | MAPTGALR3SMN1; SMN2DHFRPDE4A | |
| SCHEMBL9729357 | 0.77 | GALR3 (0.45) | MAPTGALR3SMN1; SMN2PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5108998-A | CARDIOTONIC THIADIAZINE DERIVATIVES | HEUMANN PHARMA GMBH & CO. (DE) | 1992-04-28 | — | — | US | disclosed |
| EP-0399196-A1 | Diazine derivatives, process for their preparation, and medicaments containing these compounds | HEUMANN PHARMA GMBH & CO (DE) | 1990-11-28 | — | — | EP | disclosed |