Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.40 |
| ▸ | PAM | P19021 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | PPID | Q08752 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL506200 | 0.98 | KMT2A (0.43) | KMT2AMEN1ALDH1A1L3MBTL1MAPK1 | |
| Hydrochloric Acid SCHEMBL506846 | 0.96 | KMT2A (0.42) | KMT2AMEN1ALDH1A1L3MBTL1MAPK1 | |
| Hydrochloric Acid SCHEMBL6869492 | 0.94 | KMT2A (0.41) | KMT2AMEN1ALDH1A1L3MBTL1MAPK1 | |
| Hydrochloric Acid SCHEMBL26633567 | 0.82 | ALOX5 (0.57) | ALDH1A1L3MBTL1LMNA | |
| SCHEMBL16060676 | 0.80 | SOAT1 (0.45) | KMT2AMEN1ALDH1A1L3MBTL1MAPK1 | |
| Hydrochloric Acid SCHEMBL13835179 | 0.80 | IDO1 (0.44) | KMT2AMEN1ALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL12390375 | 0.80 | ESR1 (0.46) | KMT2AALDH1A1TP53LMNAHSD17B10 | |
| Hydrochloric Acid SCHEMBL13836304 | 0.80 | MEN1 (0.46) | KMT2AMEN1ALDH1A1L3MBTL1LMNA | |
| SCHEMBL24574882 | 0.78 | KMT2A (0.45) | KMT2AMEN1L3MBTL1MAPK1SMN1; SMN2 | |
| SCHEMBL11534926 | 0.78 | MAPT (0.48) | KMT2AMEN1ALDH1A1L3MBTL1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5102667-A | Antiallergens, antiinflammatory agents, nervous system disorders, immunology, psychological disorders | RHONE-POULENC SANTE (FR) | 1992-04-07 | — | — | US | disclosed |