Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 2/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.34 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14336919 | 0.81 | SLC6A4 (0.38) | KDM1ASLC6A4SLC6A3SLC6A2HSD11B1 | |
| SCHEMBL31067194 | 0.81 | SLC6A4 (0.38) | KDM1ASLC6A4SLC6A3SLC6A2HSD11B1 | |
| SCHEMBL9729263 | 0.81 | SLC6A4 (0.40) | MGLLSLC6A4SLC6A3SLC6A2HSD11B1 | |
| SCHEMBL5875966 | 0.81 | CYP2C9 (0.37) | HSD11B1OPRM1OPRL1OPRD1OPRK1 | |
| SCHEMBL9729483 | 0.81 | HDAC4 (0.40) | MGLLHSD11B1HTR2AHTR2COPRM1 | |
| SCHEMBL5876222 | 0.80 | DAO (0.35) | MGLLSLC6A4SLC6A3SLC6A2HSD11B1 | |
| SCHEMBL744007 | 0.79 | MEN1 (0.44) | HSD11B1OPRM1OPRL1OPRK1 | |
| SCHEMBL9729613 | 0.70 | HDAC4 (0.38) | MGLLHSD11B1PSEN1PSEN2APH1B | |
| SCHEMBL14531844 | 0.70 | PDE4B (0.48) | SLC6A4 | |
| SCHEMBL14260464 | 0.70 | PDE4B (0.48) | SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5112988-A | ISOINDOLONE DERIVATIVES | RHONE-POULENC SANTE (FR) | 1992-05-12 | — | — | US | disclosed |
| US-5102667-A | Antiallergens, antiinflammatory agents, nervous system disorders, immunology, psychological disorders | RHONE-POULENC SANTE (FR) | 1992-04-07 | — | — | US | disclosed |