Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPRT1 | P00492 | 8/20 | 0.51 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.48 |
| ▸ | CDK2 | P24941 | 3/20 | 0.48 |
| ▸ | CDK1 | P06493 | 2/20 | 0.48 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | VCP | P55072 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL172847 | 0.91 | HPRT1 (0.55) | HPRT1CCNE1CDK2CDK1CCNB1 | |
| SCHEMBL15516660 | 0.91 | HPRT1 (0.55) | HPRT1CCNE1CDK2CDK1CCNB1 | |
| SCHEMBL29450587 | 0.91 | HPRT1 (0.55) | HPRT1CCNE1CDK2CDK1CCNB1 | |
| SCHEMBL97265 | 0.87 | CYP3A4 (0.62) | CCNE1CDK2CDK1CCNB1CYP3A4 | |
| SCHEMBL10047654 | 0.86 | CYP3A4 (0.64) | CYP3A4FGFR1SLC22A6ALDH1A1CYP2D6 | |
| SCHEMBL14669190 | 0.84 | CYP3A4 (0.53) | HPRT1CCNE1CDK2CDK1CCNB1 | |
| SCHEMBL14669210 | 0.84 | CYP3A4 (0.53) | HPRT1CCNE1CDK2CDK1CCNB1 | |
| SCHEMBL14669198 | 0.84 | CYP3A4 (0.53) | HPRT1CCNE1CDK2CDK1CCNB1 | |
| SCHEMBL14669074 | 0.82 | CDK1 (0.45) | HPRT1CCNE1CDK2CDK1CCNB1 | |
| SCHEMBL97316 | 0.82 | HPRT1 (0.75) | HPRT1CYP3A4MEN1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120058975-A1 | Phosphonate Compounds | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2012-03-08 | — | — | US | disclosed |
| US-8008308-B2 | Phosphonate compounds | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-08-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120058975-A1 | Phosphonate Compounds | PHPT1, PHOSPHO1, PIK3CA | HPRT1 130/4885CCNE1 943/4885CDK2 335/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.