Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MLNR | O43193 | 1/20 | 0.47 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | FYN | P06241 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10560492 | 0.98 | CYP2D6 (0.44) | CYP2D6MEN1LMNATP53KMT2A | |
| SCHEMBL1233909 | 0.98 | CYP2D6 (0.44) | CYP2D6MEN1LMNATP53KMT2A | |
| SCHEMBL9122889 | 0.98 | CYP2D6 (0.44) | CYP2D6MEN1LMNATP53KMT2A | |
| Hydrochloric Acid SCHEMBL1190314 | 0.96 | KMT2A (0.42) | CYP2D6MEN1LMNATP53KMT2A | |
| SCHEMBL588857 | 0.91 | — | — | |
| SCHEMBL1401177 | 0.91 | — | — | |
| SCHEMBL10059315 | 0.91 | — | — | |
| Hydrochloric Acid SCHEMBL20520978 | 0.89 | GHSR (0.35) | CYP2D6MEN1LMNATP53KMT2A | |
| Hydrochloric Acid SCHEMBL22495082 | 0.89 | GHSR (0.35) | CYP2D6MEN1LMNATP53KMT2A | |
| Hydrochloric Acid SCHEMBL1190877 | 0.89 | GHSR (0.35) | CYP2D6MEN1LMNATP53KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE33906-E | Cyclic carboxamide derivatives and their use as analgesics | DR.LO.ZAMBELETTI S.P.A. (IT) | 1992-04-28 | — | — | US | disclosed |
| EP-0232612-B1 | AZACYCLIC COMPOUNDS, PROCESSES FOR THEIR PREPARATION, AND THEIR USE AS PHARMACEUTICALS | Dr. Lo. Zambeletti S.p.A. (IT) | 1990-04-04 | — | — | EP | disclosed |
| US-4801585-A | Cyclic carboxamide derivatives and their use as analgesics | DR.LO.ZAMBELETTI S.P.A. (IT) | 1989-01-31 | — | — | US | disclosed |
| EP-0232612-A1 | Azacyclic compounds, processes for their preparation, and their use as pharmaceuticals | Dr. Lo. Zambeletti S.p.A. (IT) | 1987-08-19 | — | — | EP | disclosed |