SCHEMBL9730627

SCHEMBL9730627

COc1cc(OC)nc(NC(=O)NS(=O)(=O)c2cc(Cl)ccc2Cl)n1

nearest known ligand 0.59

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.59
CDK1 P06493 1/20 0.52
CCR4 P51679 1/20 0.47
CYP1A2 P05177 1/20 0.46
KDM4E B2RXH2 1/20 0.45
NPC1 O15118 1/20 0.45
ALDH1A1 P00352 1/20 0.45
TSHR P16473 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10454399 0.93 TSHR (0.54) GAACDK1CCR4KDM4ENPC1
SCHEMBL10888832 0.87 GAA (0.56) GAACDK1CYP1A2ALDH1A1TSHR
SCHEMBL10888840 0.85 GAA (0.54) GAACDK1CYP1A2TSHR
SCHEMBL28989953 0.85 GAA (0.54) GAACDK1CYP1A2KDM4ENPC1
SCHEMBL11072374 0.85 GAA (0.55) GAACDK1CYP1A2
SCHEMBL11562213 0.83 GAA (0.51) GAACDK1KDM4ENPC1ALDH1A1
SCHEMBL10616134 0.82 GAA (0.67) GAACDK1CYP1A2KDM4ENPC1
SCHEMBL11089667 0.81 TSHR (0.51) GAACDK1TSHR
SCHEMBL11043336 0.81 GAA (0.56) GAACDK1CYP1A2KDM4ENPC1
SCHEMBL11265505 0.81 KDM4E (0.55) GAACDK1KDM4ENPC1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4343649-A SULFONYLUREA HERBICIDES; NAPHTHALIC ANHYDRIDE, 2-(CYANOMETHOXYIMINO)BENZACETONITRILE, N,N-DIALLYL-2,2-DICHLOROACETAMIDE E. I. DU PONT DE NEMOURS AND COMPANY (US) 1982-08-10 US claimed
US-4169719-A Herbicidal sulfonamides E. I. DU PONT DE NEMOURS AND CO. (US) 1979-10-02 US claimed
US-5102445-A Plant safening agent CIBA-GEIGY CORPORATION (US) 1992-04-07 US disclosed
US-5045107-A From herbicides, plant safening agents CIBA-GEIGY CORPORATION (US) 1991-09-03 US disclosed
US-5023333-A Derivatives of 8-hydroxyquinoline CIBA-GEIGY CORPORATION (US) 1991-06-11 US disclosed
US-4902340-A Use of quinoline derivatives for the protection of cultivated plants from herbicides CIBA-GEIGY CORPORATION (US) 1990-02-20 US disclosed
US-4851033-A Use of quinoline derivatives for the protection of cultivated plants CIBA-GEIGY CORPORATION (US) 1989-07-25 US disclosed
US-4822884-A PLANT SAFENING AGENTS CIBA-GEIGY CORPORATION (US) 1989-04-18 US disclosed
US-4785106-A PLANT SAFENING AGENTS FOR HERBICIDES CIBA-GEIGY CORPORATION (US) 1988-11-15 US disclosed
US-4785105-A PROTECTION OF PLANTS AGAINST HERBICIDES CIBA-GEIGY CORPORATION (US) 1988-11-15 US disclosed
US-4758264-A Selectively controlling weeds in crops CIBA-GEIGY CORPORATION (US) 1988-07-19 US disclosed
US-4645527-A PLANT SAFENING AGENT E. I. DU PONT DE NEMOURS AND COMPANY (US) 1987-02-24 US disclosed
US-4623727-A PLANT SAFENING AGENTS CIBA-GEIGY CORPORATION (US) 1986-11-18 US disclosed
US-4618361-A COUNTER-AGENT OR SAFENER CIBA-GEIGY CORPORATION (US) 1986-10-21 US disclosed
US-4601745-A Composition for the protection of cultivated plants against the phytotoxic action of herbicides CIBA-GEIGY CORPORATION (US) 1986-07-22 US disclosed
US-4505738-A Halovinyl-3,3-dimethylcyclopropanecarboxylic acid pyronyl esters useful for the protection of cultivated plants against the harmful effects of herbicides CIBA-GEIGY CORPORATION (US) 1985-03-19 US disclosed
EP-0127469-A2 Antidotes for sulfonylurea herbicides E.I. DU PONT DE NEMOURS AND COMPANY (US) 1984-12-05 EP disclosed
US-4483707-A PLANT SAFTENING AGENTS CIBA-GEIGY CORPORATION (US) 1984-11-20 US disclosed
US-4343649-A SULFONYLUREA HERBICIDES; NAPHTHALIC ANHYDRIDE, 2-(CYANOMETHOXYIMINO)BENZACETONITRILE, N,N-DIALLYL-2,2-DICHLOROACETAMIDE E. I. DU PONT DE NEMOURS AND COMPANY (US) 1982-08-10 US disclosed
US-4169719-A Herbicidal sulfonamides E. I. DU PONT DE NEMOURS AND CO. (US) 1979-10-02 US disclosed