Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA2 | P42262 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 10/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.37 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9365099 | 1.00 | GRIA2 (0.40) | GRIA2KDM1ANPC1RXFP1AURKA | |
| SCHEMBL9366626 | 0.90 | GRIA2 (0.39) | GRIA2KDM1ANPC1RXFP1AURKA | |
| SCHEMBL9366634 | 0.90 | GRIA2 (0.39) | GRIA2KDM1ANPC1RXFP1AURKA | |
| SCHEMBL9366591 | 0.88 | GRIA2 (0.38) | GRIA2KDM1ANPC1RXFP1AURKA | |
| SCHEMBL9366580 | 0.88 | GRIA2 (0.38) | GRIA2KDM1ANPC1RXFP1AURKA | |
| SCHEMBL9370824 | 0.87 | KDM1A (0.50) | KDM1AMAOBGRM5DGAT1 | |
| SCHEMBL9366265 | 0.87 | GRIA2 (0.37) | GRIA2KDM1ANPC1RXFP1AURKA | |
| SCHEMBL9366256 | 0.87 | GRIA2 (0.37) | GRIA2KDM1ANPC1RXFP1AURKA | |
| SCHEMBL9366501 | 0.86 | GRM2 (0.43) | KDM1ANPC1MAOBCYP11B1CYP11B2 | |
| SCHEMBL9731106 | 0.86 | GRM2 (0.43) | KDM1ANPC1MAOBCYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5160661-A | DIOXANYLPYRIDINE | HOFFMANN-LA ROCHE INC. (US) | 1992-11-03 | — | — | US | disclosed |